Well Referenced

Tag: older adults

Statins for primary prevention of cardiovascular events and mortality in old and very old adults with and without type 2 diabetes: retrospective cohort study

This retrospective cohort study analyzed data from 46,864 individuals aged 75 and older without clinically recognized atherosclerotic cardiovascular disease (CVD) to evaluate the impact of statin therapy on primary prevention. Over a median follow-up of 5.6 years, statin use did not significantly reduce CVD events or all-cause mortality in those

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June 26, 2025 No Comments

Citicoline and Memory Function in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

This randomized, double-blind, placebo-controlled trial examined the effects of citicoline supplementation (500 mg/day for 12 weeks) on memory function in 100 healthy older adults (ages 50-85) with age-associated memory impairment (AAMI). The citicoline group showed significant improvements in episodic memory (p=0.0025) and overall memory performance (p=0.0052) compared to the placebo.

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June 26, 2025 No Comments

Coenzyme Q10 as Adjunctive Therapy for Cardiovascular Disease and Hypertension: A Systematic Review

This systematic review analyzed 14 studies involving 1,067 predominantly older adult males and evaluated the effectiveness of Coenzyme Q10 (CoQ10) as adjunctive therapy in patients with cardiovascular disease (CVD) and hypertension. Findings indicated that CoQ10 supplementation improved functional capacity in heart failure patients, increased serum CoQ10 levels, reduced major cardiovascular

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June 26, 2025 No Comments

Physical enhancement of older adults using hyperbaric oxygen: a randomized controlled trial

This randomized controlled trial examined the effects of hyperbaric oxygen therapy (HBOT) on physical performance and muscle mass in healthy older adults, demonstrating significant improvements in muscle function and exercise capacity. HBOT, which involves breathing pure oxygen in a pressurized environment, enhances oxygen availability in tissues, stimulating angiogenesis, reducing inflammation,

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June 26, 2025 No Comments

The Effect of 600 mg Alpha-lipoic Acid Supplementation on Oxidative Stress, Inflammation, and RAGE in Older Adults with Type 2 Diabetes Mellitus

This quasi-experimental study examined the effects of 600 mg/day alpha-lipoic acid (ALA) supplementation for six months on oxidative stress, inflammation, and RAGE levels in 135 sedentary older adults with type 2 diabetes mellitus (T2DM). The study found a statistically significant decrease (p < 0.05) in 8-isoprostane levels and RAGE concentrations

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June 26, 2025 No Comments

Sex-specific effects of dehydroepiandrosterone (DHEA) on bone mineral density and body composition: A pooled analysis of four clinical trials

This pooled analysis of four randomized controlled trials examined the sex-specific effects of dehydroepiandrosterone (DHEA) therapy on bone mineral density (BMD) and body composition in older adults. The study found that DHEA supplementation led to a 1.0% increase in lumbar spine BMD in women over 12 months, while men experienced

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June 26, 2025 No Comments

Factors influencing the efficacy of nutritional interventions on muscle mass in older adults: a systematic review and meta-analysis

This 2021 systematic review and meta-analysis evaluated 29 randomized controlled trials involving 2,255 older adults (mean age 78.1 years) to assess the impact of nutritional interventions on muscle mass. The findings indicate that supplementation with amino acids, creatine, β-hydroxy-β-methylbutyrate (HMB), and protein combined with amino acids significantly improved muscle mass,

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June 26, 2025 No Comments

Distribution and determinants of C-reactive protein in the older adult population: European Prospective Investigation into Cancer-Norfolk study

This observational study from the EPIC-Norfolk cohort examined the distribution and determinants of C-reactive protein (CRP) levels in 18,586 adults aged 40-79 years, with follow-up measurements in 6,087 individuals over 13 years. Higher CRP levels were associated with older age, female sex, higher BMI, smoking, and physical inactivity, with these

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June 26, 2025 No Comments