This randomized, double-blind, placebo-controlled trial examined the effects of citicoline supplementation (500 mg/day for 12 weeks) on memory function in 100 healthy older adults (ages 50-85) with age-associated memory impairment (AAMI). The citicoline group showed significant improvements in episodic memory (p=0.0025) and overall memory performance (p=0.0052) compared to the placebo.
