Well Referenced

Tag: older adults

Obesity and Onset of Depression Among U.S. Middle-Aged and Older Adults

This longitudinal study analyzed data from 6,514 U.S. adults born between 1931 and 1941, who were free of clinically relevant depressive symptoms in 1994. Over a 16-year follow-up period, the study found that overweight and obese individuals had a higher risk of developing depression compared to those with normal weight.

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June 26, 2025 No Comments

Weight loss in obese older adults increases serum sclerostin and impairs hip geometry but both are prevented by exercise training

This randomized controlled trial evaluated the effects of weight loss, with or without exercise, on serum sclerostin levels and hip geometry in 107 obese adults aged ≥65 years. Participants were assigned to one of four groups: control, diet-induced weight loss, exercise, or combined diet-exercise, over 12 months. The diet group

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June 26, 2025 No Comments

Does L-Citrulline Supplementation Improve Exercise Blood Flow in Older Adults?

This 2017 randomized, double-blind, placebo-controlled crossover study investigated the effects of L-citrulline supplementation on exercise-induced blood flow in older adults. Twenty-five participants (13 women and 12 men) received 6 grams per day of L-citrulline or a placebo for 14 days. Femoral artery blood flow and vascular conductance were measured during

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June 26, 2025 No Comments

Immunologic Changes in Frail Older Adults

This review article explores the immunological alterations associated with frailty in older adults. Frailty is characterized by a heightened inflammatory state, evidenced by elevated serum levels of interleukin-6 (IL-6) and C-reactive protein (CRP), and an increased number of circulating monocytes. These changes reflect a chronic, low-grade inflammation known as “inflammaging.”

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June 26, 2025 No Comments

Yeast-derived β-1,3/1,6 Glucan, Upper Respiratory Tract Infection and Innate Immunity in Older Adults

This randomized, double-blind, placebo-controlled trial investigated the effects of yeast-derived β-1,3/1,6-glucan supplementation on upper respiratory tract infections (URTIs) and innate immunity in older adults. Participants aged 50–70 years received either 250 mg/day of β-glucan or a placebo for 90 days. The study found that β-glucan supplementation significantly reduced the incidence

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June 26, 2025 No Comments

Primary Prevention with Lipid Lowering Drugs and Long-Term Risk of Vascular Events in Older People: Population-Based Cohort Study

This population-based cohort study from France included 7,484 community-dwelling adults aged 65 years and older without a history of vascular events. It aimed to assess whether lipid-lowering drugs (mainly statins and fibrates) reduce the long-term risk of stroke and coronary heart disease (CHD) in a primary prevention setting. Over a

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June 26, 2025 No Comments

Risks of Statin Therapy in Older Adults

This expert commentary reviews the concerns surrounding statin therapy in adults aged 75 and older, particularly in the context of primary prevention of cardiovascular disease (CVD). While statins are proven to reduce cardiovascular events in younger populations, the evidence in older adults is less definitive, especially for those without established

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June 26, 2025 No Comments

Chronic Supplementation With a Mitochondrial Antioxidant (MitoQ) Improves Vascular Function in Healthy Older Adults

This randomized, double-blind, placebo-controlled crossover trial examined the impact of 6 weeks of MitoQ (20 mg/day) supplementation on vascular function in 20 healthy older adults aged 60–79 years with baseline endothelial dysfunction. MitoQ significantly enhanced brachial artery flow-mediated dilation (FMD) by 42% relative to placebo, indicating improved endothelial function. Among

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June 26, 2025 No Comments