Well Referenced

Tag: older adults

Effects of combined cognitive and exercise interventions on cognition in older adults with and without cognitive impairment: a systematic review

This 2014 systematic review evaluated the impact of combined cognitive training and physical exercise on cognitive outcomes in older adults, with and without cognitive impairment. Analyzing data from eight studies, the review found that these multi-domain interventions generally improved cognitive function, particularly in memory, executive function, and attention. The benefits

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June 26, 2025 No Comments

All cause mortality and the case for age specific alcohol consumption guidelines: pooled analyses of up to 10 population based cohorts

This 2015 study analyzed data from up to 10 Health Survey for England cohorts to assess the relationship between alcohol consumption and all-cause mortality among adults aged 50 and above. The findings indicated that any protective effects of alcohol consumption were largely confined to women aged 65 and older, particularly

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June 26, 2025 No Comments

A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive effects

This 2018 pilot study assessed the safety and feasibility of daily 1 mg rapamycin administration over 8 weeks in 25 healthy older adults aged 70–95. The treatment was generally well-tolerated, with minor adverse events including facial rash, stomatitis, and gastrointestinal discomfort. Notably, there were statistically significant reductions in erythrocyte parameters

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June 26, 2025 No Comments

Inflammatory age and its impact on age-related health in older Chinese adults

This observational study introduces the concept of inflammatory age (iAge) to quantify age-related inflammation and explores its relationship with various metabolic and cardiovascular conditions among older Chinese adults. Increased iAge correlated significantly with higher BMI, waist circumference, A1c levels, systolic blood pressure, triglycerides, and cardiovascular disease risk, as well as

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June 26, 2025 No Comments

Soluble TNFR1 has greater reproducibility than IL-6 for the assessment of chronic inflammation in older adults: the case for a new inflammatory marker in aging

This cohort study evaluated the reliability of serum biomarkers for chronic inflammation (CI) in older adults, comparing soluble tumor necrosis factor receptor 1 (sTNFR1) with interleukin-6 (IL-6). Results showed that sTNFR1 had significantly greater reproducibility over time, with intra-class correlation coefficients (ICC) of 0.95 at 6 weeks and 0.79 at

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June 26, 2025 No Comments

Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell profiles and epigenetic ageing

This cohort study examined the trajectories of inflammatory biomarkers (C-reactive protein and interleukin-6) in individuals aged 70 to 79 and their associations with epigenetic age acceleration. Over time, low-sensitivity CRP decreased, high-sensitivity CRP remained stable, and IL-6 increased. Elevated levels of these biomarkers were associated with higher extrinsic epigenetic age

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June 26, 2025 No Comments

Elevated fecal calprotectin is associated with gut microbial dysbiosis, altered serum markers and clinical outcomes in older individuals

This observational study of 735 older adults found that elevated fecal calprotectin levels correlated with gut microbial dysbiosis, higher pro-inflammatory serum markers, and increased prevalence of conditions like obesity and heart attacks. Participants with fecal calprotectin levels above 100 μg/g exhibited significant changes in gut microbiota, reduced short-chain fatty acid-producing

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June 26, 2025 No Comments

Anemia in Older Adults

This review article discusses the evaluation and management of anemia in older adults, a condition associated with increased morbidity and mortality. It highlights that anemia is frequently asymptomatic but can present with fatigue, weakness, or shortness of breath. Common causes include iron deficiency, chronic kidney disease, inflammation, and gastrointestinal blood

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June 26, 2025 No Comments