Well Referenced

Tag: Metformin

Still Living Better through Chemistry: An Update on Caloric Restriction and Caloric Restriction Mimetics as Tools to Promote Health and Lifespan

This 2020 review explores how caloric restriction (CR) and caloric restriction mimetics (CRMs) enhance healthspan and lifespan through modulation of key nutrient-sensing pathways, including IGF-1, mTOR, and AMPK. CR has been associated with improved metabolic parameters, reduced inflammation, and extended lifespan in multiple species. CRMs—such as resveratrol, metformin, and rapamycin—aim

Read More »
June 26, 2025 No Comments

Metformin: do we finally have an anti-aging drug?

This review by Vladimir N. Anisimov explores the potential of antidiabetic biguanides, particularly metformin, as anti-aging agents. Drawing from studies in various organisms—including nematodes, fruit flies, and rodents—the article highlights how metformin reduces hyperglycemia and hyperinsulinemia, factors implicated in aging and cancer. Metformin’s mechanisms involve decreasing insulin resistance and modulating

Read More »
June 26, 2025 No Comments

Metformin improves putative longevity effectors in peripheral mononuclear cells from subjects with prediabetes. A randomized controlled trial

This randomized, single-blind, placebo-controlled trial evaluated the impact of metformin on longevity-associated pathways in 38 prediabetic individuals over two months. Participants received either metformin (1500 mg/day) or placebo. Metformin treatment led to significant improvements in metabolic parameters and insulin sensitivity. Notably, there was an increase in SIRT1 gene and protein

Read More »
June 26, 2025 No Comments

Comparison of metformin plus myoinositol vs metformin alone in PCOS women undergoing ovulation induction cycles: randomized controlled trial

This randomized controlled trial compared the effectiveness of Metformin plus Myoinositol versus Metformin alone in improving fertility outcomes for women with polycystic ovary syndrome (PCOS) undergoing ovulation induction. The study found that the combination of Metformin and Myoinositol significantly increased the live birth rate (55%) compared to Metformin alone (26.67%).

Read More »
June 26, 2025 No Comments

Comparison of myo-inositol and metformin on glycemic control, lipid profiles, and gene expression related to insulin and lipid metabolism in women with polycystic ovary syndrome: a randomized controlled clinical trial

This randomized controlled trial compared the effects of Myo-Inositol and Metformin on glycemic control, lipid profiles, and gene expression related to insulin and lipid metabolism in women with polycystic ovary syndrome (PCOS). The study found that both treatments improved insulin sensitivity and lipid metabolism, but Myo-Inositol showed superior results, particularly

Read More »
June 26, 2025 No Comments