Well Referenced

Tag: Metformin

Metformin for Weight Reduction in Non-Diabetic Patients on Antipsychotic Drugs: A Systematic Review and Meta-Analysis

This 2011 systematic review and meta-analysis evaluated the efficacy of metformin in mitigating weight gain induced by atypical antipsychotics in non-diabetic patients. Analyzing seven randomized, placebo-controlled trials encompassing 398 participants (five studies in adults and two in children), the study found that metformin significantly reduced body weight compared to placebo.

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June 26, 2025 No Comments

The Effects of Metformin or Orlistat on Obese Women with Polycystic Ovary Syndrome: A Prospective Randomized Open-Label Study

This 2011 prospective randomized open-label study compared the effects of metformin and orlistat on hormonal profiles, lipid parameters, and ovulation rates in 80 obese women with PCOS over a 3-month period. Both treatments led to significant reductions in body weight, BMI, and waist circumference, with no significant difference between the

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June 26, 2025 No Comments

Of Mice and Men: The Benefits of Caloric Restriction, Exercise, and Mimetics

This review explores the physiological and molecular effects of caloric restriction (CR), exercise, and pharmacological mimetics on aging and metabolic health. CR has been shown to extend both mean and maximum lifespan in animal models by activating stress response pathways and enhancing mitochondrial function. Exercise primarily improves healthspan, delaying the

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June 26, 2025 No Comments

Metformin directly inhibits ghrelin secretion through AMP-activated protein kinase in rat primary gastric cells

This 2013 study investigated the direct effects of metformin on ghrelin secretion in rat primary gastric cells. The researchers found that metformin significantly reduced ghrelin secretion and proghrelin mRNA levels. These inhibitory effects were mediated through the activation of AMP-activated protein kinase (AMPK), as co-incubation with the AMPK inhibitor compound

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June 26, 2025 No Comments

Short-term combined treatment with liraglutide and metformin leads to significant weight loss in obese women with polycystic ovary syndrome and previous poor response to metformin

This 12-week open-label, prospective study evaluated the efficacy of combining liraglutide (1.2 mg/day subcutaneously) with metformin (1000 mg twice daily) in 40 obese, non-diabetic women with PCOS who had previously lost less than 5% body weight on metformin monotherapy. Participants were randomized into three groups: metformin alone (MET), liraglutide alone

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June 26, 2025 No Comments

The effects of metformin on autophagy

This 2021 review article explores the multifaceted role of metformin in modulating autophagy across various biological systems. Metformin primarily induces autophagy through activation of AMP-activated protein kinase (AMPK), leading to inhibition of the mTOR pathway. It also influences other signaling pathways, including AMPK/CEBPD, MiTF/TFE, AMPK/ULK1, and AMPK/miR-221. Additionally, metformin can

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June 26, 2025 No Comments

Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis

This 2012 systematic review and meta-analysis assessed the efficacy and safety of berberine in managing type 2 diabetes mellitus (T2DM). Analyzing 14 randomized controlled trials involving 1,068 participants, the study found that berberine significantly improved glycemic control and lipid profiles compared to lifestyle modifications or placebo. When compared to standard

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June 26, 2025 No Comments

Weight Beneficial Treatments for Type 2 Diabetes

This review examines the impact of “weight-friendly” pharmacotherapies in the management of type 2 diabetes mellitus (T2DM), emphasizing the importance of considering the weight effects of different treatment regimens. It highlights that certain antidiabetic agents, such as metformin, GLP-1 receptor agonists, and SGLT2 inhibitors, are associated with weight neutrality or

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June 26, 2025 No Comments