Still Living Better through Chemistry: An Update on Caloric Restriction and Caloric Restriction Mimetics as Tools to Promote Health and Lifespan

This 2020 review explores how caloric restriction (CR) and caloric restriction mimetics (CRMs) enhance healthspan and lifespan through modulation of key nutrient-sensing pathways, including IGF-1, mTOR, and AMPK. CR has been associated with improved metabolic parameters, reduced inflammation, and extended lifespan in multiple species. CRMs—such as resveratrol, metformin, and rapamycin—aim