Well Referenced

Tag: intra-articular injection

Intra-articular Injections of Expanded Mesenchymal Stem Cells with and without Addition of Platelet-Rich Plasma Are Safe and Effective for Knee Osteoarthritis

This randomized controlled trial evaluated the safety and efficacy of intra-articular injections of autologous expanded mesenchymal stem cells (MSCs) alone or combined with platelet-rich plasma (PRP) in 18 patients with symptomatic knee osteoarthritis (OA). Participants were randomized to receive either MSCs alone or MSCs plus PRP. Both groups demonstrated significant

Read More »
June 26, 2025 No Comments

Umbilical Cord-Derived Mesenchymal Stromal Cells (MSCs) for Knee Osteoarthritis: Repeated MSC Dosing Is Superior to a Single MSC Dose and to Hyaluronic Acid in a Controlled Randomized Phase I/II Trial

This Phase I/II randomized controlled trial assessed the safety and efficacy of intra-articular injections of umbilical cord-derived mesenchymal stromal cells (UC-MSCs) in patients with symptomatic knee osteoarthritis (OA). Participants were randomized into three groups: hyaluronic acid (HA) injections at baseline and 6 months (n=8), a single UC-MSC dose at baseline

Read More »
June 26, 2025 No Comments

Safety and Efficacy of Allogenic Placental Mesenchymal Stem Cells for Treating Knee Osteoarthritis: A Pilot Study

This double-blind, placebo-controlled pilot study evaluated the safety and efficacy of intra-articular injections of allogenic placental mesenchymal stem cells (MSCs) in 20 patients with symptomatic knee osteoarthritis (OA). Participants received either 0.5–0.6 × 10⁸ allogenic placenta-derived MSCs or saline placebo. Over 24 weeks, the MSC group demonstrated significant improvements in

Read More »
June 26, 2025 No Comments

Treatment of Femoral Head Osteonecrosis with Ozone Therapy: Pilot Trial of a New Therapeutic Approach

This 2022 nonrandomized clinical trial evaluated the efficacy of ozone therapy in patients with osteonecrosis of the femoral head (ONFH). Seventy-one patients (107 hips) with ARCO stage I–IV ONFH were assigned to receive either intra-articular ozone injections combined with ozonated autohemotherapy (n=39, 58 hips) or standard protected weight-bearing care (n=32,

Read More »
June 26, 2025 No Comments

Intra-articular ozone or hyaluronic acid injection: Which one is superior in patients with knee osteoarthritis? A 6-month randomized clinical trial

This 2018 randomized clinical trial evaluated the efficacy of intra-articular ozone injections versus hyaluronic acid (HA) in 174 patients with knee osteoarthritis. Participants received three weekly injections of either 10 mL ozone (30 μg/mL) or HA (Hyalgan®). Outcomes assessed at baseline and 6 months included pain (VAS) and function (WOMAC).

Read More »
June 26, 2025 No Comments

Efficacy of combined ozone and platelet-rich-plasma treatment versus platelet-rich-plasma treatment alone in early stage knee osteoarthritis

This 2019 retrospective study compared the outcomes of intra-articular platelet-rich plasma (PRP) injections alone versus PRP combined with ozone therapy in patients with early-stage knee osteoarthritis (KOA). The study included 80 patients—45 received PRP alone, and 35 received PRP plus ozone. Both groups exhibited significant improvements in pain (VAS) and

Read More »
June 26, 2025 No Comments

The comparison effects of intra-articular injection of Platelet Rich Plasma (PRP), Plasma Rich in Growth Factor (PRGF), Hyaluronic Acid (HA), and ozone in knee osteoarthritis; a one year randomized clinical trial

This 2021 randomized clinical trial evaluated the short- and long-term efficacy of intra-articular injections of PRP, PRGF, HA, and ozone in 200 patients with mild to moderate knee osteoarthritis. Patients were randomized into four groups: PRP (2 doses, 3-week interval), PRGF (2 doses, 3-week interval), HA (3 weekly doses), and

Read More »
June 26, 2025 No Comments

Oxygen-Ozone Therapy for the Treatment of Knee Osteoarthritis: A Systematic Review of Randomized Controlled Trials

This 2020 systematic review analyzed 11 randomized controlled trials involving 858 patients to assess the efficacy and safety of intra-articular oxygen-ozone therapy (OOT) for knee osteoarthritis (KOA). The studies compared OOT with various treatments, including placebo, hyaluronic acid, corticosteroids, platelet-rich plasma, hypertonic dextrose, radiofrequency, and celecoxib plus glucosamine. While OOT

Read More »
June 26, 2025 No Comments

Therapeutic effects of prolotherapy with intra-articular dextrose injection in patients with moderate knee osteoarthritis: a single-arm study with 6 months follow-up

This 2015 prospective single-arm study evaluated the efficacy of intra-articular dextrose prolotherapy in 24 female patients (mean age 58.4 years) with moderate knee osteoarthritis. Patients received three injections of 20% dextrose at baseline, 4 weeks, and 8 weeks. Outcomes measured over 24 weeks included pain (VAS), range of motion (ROM),

Read More »
June 26, 2025 No Comments

Ozone Therapy in Knee Osteoarthritis: A Systematic Review

This 2018 systematic review analyzed six randomized controlled trials assessing the efficacy of ozone therapy in knee osteoarthritis (KOA). The studies primarily involved elderly patients with mild to moderate KOA. Findings indicated that ozone therapy provided short-term pain relief, particularly when combined with hyaluronic acid, but was not superior to

Read More »
June 26, 2025 No Comments