This 2020 systematic review analyzed 11 randomized controlled trials involving 858 patients to assess the efficacy and safety of intra-articular oxygen-ozone therapy (OOT) for knee osteoarthritis (KOA). The studies compared OOT with various treatments, including placebo, hyaluronic acid, corticosteroids, platelet-rich plasma, hypertonic dextrose, radiofrequency, and celecoxib plus glucosamine. While OOT
