This 2022 nonrandomized clinical trial evaluated the efficacy of ozone therapy in patients with osteonecrosis of the femoral head (ONFH). Seventy-one patients (107 hips) with ARCO stage I–IV ONFH were assigned to receive either intra-articular ozone injections combined with ozonated autohemotherapy (n=39, 58 hips) or standard protected weight-bearing care (n=32,