Well Referenced

Tag: interleukin-6

No differential effect of beverages sweetened with fructose, high-fructose corn syrup, or glucose on systemic or adipose tissue inflammation in normal-weight to obese adults: a randomized controlled trial

This randomized, double-blind, crossover trial investigated the effects of consuming beverages sweetened with fructose, high-fructose corn syrup (HFCS), or glucose on systemic and adipose tissue inflammation in 24 adults ranging from normal weight to obese. Over three 8-day periods, participants consumed 4 servings per day of each sweetened beverage, accounting

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June 26, 2025 No Comments

Whole grain-rich diet reduces body weight and systemic low-grade inflammation without inducing major changes of the gut microbiome: a randomised cross-over trial

This 2019 randomized cross-over trial investigated the effects of a whole grain-rich diet compared to a refined grain diet on body weight, systemic inflammation, and gut microbiome composition in 60 Danish adults at risk of metabolic syndrome. Participants underwent two 8-week dietary intervention periods, separated by a washout period of

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June 26, 2025 No Comments

Immunologic Changes in Frail Older Adults

This review article explores the immunological alterations associated with frailty in older adults. Frailty is characterized by a heightened inflammatory state, evidenced by elevated serum levels of interleukin-6 (IL-6) and C-reactive protein (CRP), and an increased number of circulating monocytes. These changes reflect a chronic, low-grade inflammation known as “inflammaging.”

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June 26, 2025 No Comments

Oxygen-Ozone Therapy for Reducing Pro-Inflammatory Cytokines Serum Levels in Musculoskeletal and Temporomandibular Disorders: A Comprehensive Review

This 2022 review article published in the International Journal of Molecular Sciences evaluates the role of oxygen-ozone (O₂O₃) therapy in modulating pro-inflammatory cytokines, particularly interleukin-6 (IL-6), in conditions such as temporomandibular disorders (TMD), low back pain, knee osteoarthritis, and rheumatic diseases. The authors highlight that O₂O₃ therapy exerts its effects

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June 26, 2025 No Comments

Is Curcumin Intake Really Effective for Chronic Inflammatory Metabolic Disease? A Review of Meta-Analyses of Randomized Controlled Trials

This systematic review analyzed 54 meta-analyses of randomized controlled trials to assess the effectiveness of curcumin supplementation in managing chronic inflammatory metabolic diseases. Curcumin was found to significantly reduce inflammatory markers like CRP, IL-6, and TNF-α; lower oxidative stress (as indicated by decreased MDA); and improve glucose metabolism (reducing FBG,

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June 26, 2025 No Comments

Inflammation and hemostasis biomarkers and cardiovascular risk in the elderly: the Cardiovascular Health Study

This observational study followed 4,510 older adults over 9 years and found that elevated levels of specific biomarkers related to inflammation and hemostasis, such as IL-6, CRP, D-dimer, homocysteine, WBC count, factor VIII, and lipoprotein(a), were significantly associated with increased cardiovascular risk. The study also noted gender differences in biomarker

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June 26, 2025 No Comments

Inflammatory, Oxidative Stress, and Cardiac Damage Biomarkers and Radiation-Induced Fatigue in Breast Cancer Survivors

This 2022 observational study (PMID: 35527686) published in Biological Research for Nursing explored the relationship between biomarkers of inflammation, oxidative stress, and cardiac damage with post-treatment fatigue in 180 postmenopausal breast cancer survivors who had undergone radiation therapy. The researchers found that higher levels of cystatin-C, IL-6, and GDF-15 were

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June 26, 2025 No Comments

Interleukin 6: at the interface of human health and disease

This 2023 review article published in Frontiers in Immunology (DOI: 10.3389/fimmu.2023.1255533) explores the central role of Interleukin-6 (IL-6) in immune regulation, inflammation, and disease. IL-6 bridges innate and adaptive immunity, influences B and T cell activity, impacts the blood-brain barrier, and contributes to systemic and localized inflammation. The review highlights

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June 26, 2025 No Comments

Interleukin-6 cytokine: An overview of the immune regulation, immune dysregulation, and therapeutic approach

This 2022 review article published in International Immunopharmacology (DOI: 10.1016/j.intimp.2022.109130) provides a comprehensive overview of Interleukin-6 (IL-6), a key cytokine involved in both immune regulation and immune dysregulation. IL-6 plays a central role in inflammation, B and T cell activity, acute-phase responses, and is pivotal in autoimmune and chronic inflammatory

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June 26, 2025 No Comments

Interleukin-6: obstacles to targeting a complex cytokine in critical illness

This 2021 review article published in The Lancet Respiratory Medicine (DOI: 10.1016/S2213-2600(21)00103-X) delves into the complex biology of interleukin-6 (IL-6), a cytokine with both pro- and anti-inflammatory roles, and its implications in critical illnesses such as sepsis, acute respiratory distress syndrome (ARDS), and severe COVID-19. The review highlights IL-6’s multiple

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June 26, 2025 No Comments