Well Referenced

Tag: interleukin-6

Interleukin-6: obstacles to targeting a complex cytokine in critical illness

This 2021 review article published in The Lancet Respiratory Medicine (DOI: 10.1016/S2213-2600(21)00103-X) delves into the complex biology of interleukin-6 (IL-6), a cytokine with both pro- and anti-inflammatory roles, and its implications in critical illnesses such as sepsis, acute respiratory distress syndrome (ARDS), and severe COVID-19. The review highlights IL-6’s multiple

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June 26, 2025 No Comments

Rapid and sensitive detection of interleukin-6 in serum via time-resolved lateral flow immunoassay

This study published in Analytical Biochemistry (DOI: 10.1016/j.ab.2019.113468) introduces a rapid, sensitive lateral flow immunoassay (LFIA) for detecting interleukin-6 (IL-6) levels in human serum. The assay, utilizing europium nanoparticles (Eu-NPs), demonstrated a detection range of 2–500 pg/mL and high sensitivity (0.37 pg/mL), with strong correlation (r = 0.9756, p <

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June 26, 2025 No Comments

Recent Advances in Electrochemical and Optical Biosensors Designed for Detection of Interleukin 6

This 2020 review published in Sensors (Basel) (DOI: 10.3390/s20030646) explores advancements in electrochemical and optical biosensors designed for the detection of Interleukin 6 (IL-6), a key biomarker in various inflammatory and autoimmune conditions. The review discusses the high specificity and sensitivity of these biosensors, highlighting their potential for early diagnosis

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June 26, 2025 No Comments

Relationship between Disease Characteristics and Circulating Interleukin 6 in a Well-Characterized Cohort of Patients with Systemic Lupus Erythematosus

This observational study explored how circulating interleukin-6 (IL-6) levels relate to various disease characteristics in 284 well-characterized patients with systemic lupus erythematosus (SLE). The researchers found IL-6 was significantly associated with older age, male gender, higher C-reactive protein (CRP), and markers of complement system activation, including C1 inhibitor and C3a.

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June 26, 2025 No Comments

Role of interleukin-6 and interferon-α in systemic lupus erythematosus: A case-control study and meta-analysis

This case-control study and accompanying meta-analysis explored the roles of interleukin-6 (IL-6) and interferon-alpha (IFN-α) in systemic lupus erythematosus (SLE). Among 70 SLE patients and 40 matched healthy controls, significantly elevated levels of IL-6 (p < 0.0001) and IFN-α (p = 0.01) were observed in SLE patients, both correlating positively

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June 26, 2025 No Comments

Serum interleukin-6 is an indicator for severity in 901 patients with SARS-CoV-2 infection: a cohort study

This cohort study of 901 patients with confirmed COVID-19 found that elevated serum interleukin-6 (IL-6) levels strongly correlate with disease severity and mortality. Critical cases had significantly higher IL-6 concentrations (median 21.55 pg/ml) than severe or common cases (P < 0.001), and IL-6 levels above 37.65 pg/ml predicted in-hospital mortality

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June 26, 2025 No Comments

Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell profiles and epigenetic ageing

This cohort study examined the trajectories of inflammatory biomarkers (C-reactive protein and interleukin-6) in individuals aged 70 to 79 and their associations with epigenetic age acceleration. Over time, low-sensitivity CRP decreased, high-sensitivity CRP remained stable, and IL-6 increased. Elevated levels of these biomarkers were associated with higher extrinsic epigenetic age

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June 26, 2025 No Comments

Anti-inflammatory effects of oral supplementation with curcumin: a systematic review and meta-analysis of randomized controlled trials

This systematic review and meta-analysis examined the anti-inflammatory effects of curcumin supplementation, incorporating data from 32 randomized controlled trials with 2,038 participants. The analysis showed significant reductions in several inflammatory markers, including C-reactive protein, interleukin-6, tumor necrosis factor-alpha, and interleukin-8, as well as an increase in interleukin-10. Curcumin supplementation also

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June 26, 2025 No Comments

Dietary patterns and associations with biomarkers of inflammation in adults: a systematic review of observational studies

This systematic review of 69 observational studies examined the relationship between dietary patterns and inflammatory biomarkers in adults. It found that adherence to healthy diets, particularly the Mediterranean and anti-inflammatory patterns, correlated with lower levels of inflammatory markers like C-reactive protein (CRP) and interleukin-6 (IL-6). Most cross-sectional studies reported significant

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June 26, 2025 No Comments

Dietary score associations with markers of chronic low-grade inflammation: a cross-sectional comparative analysis of a middle- to older-aged population

This cross-sectional study of adults aged 46–73 found that higher scores on the DASH diet were associated with lower levels of inflammatory markers like CRP, IL-6, and TNF-α. Conducted in a large Irish primary care cohort (n=1,862), the study highlighted the potential of dietary patterns rich in anti-inflammatory nutrients—like those

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June 26, 2025 No Comments