Well Referenced

Tag: Dermatology

Topical Minoxidil Fortified with Finasteride: An Account of Maintenance of Hair Density After Replacing Oral Finasteride

This 2015 retrospective study evaluated the maintenance of hair density in 50 male patients with androgenetic alopecia (AGA) who transitioned from oral finasteride to a topical formulation containing 5% minoxidil and 0.1% finasteride. After two years of oral finasteride and minoxidil therapy, patients switched to the topical regimen. Results showed

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June 26, 2025 No Comments

Pharmacologic Interventions in Aging Hair

This 2006 review by Dr. Ralph M. Trüeb addresses the biological and environmental contributors to hair aging, including genetic factors, hormonal changes, oxidative stress, and UV radiation. The article outlines established pharmacologic treatments such as topical minoxidil and oral finasteride, which are effective for androgenetic alopecia and age-related hair thinning.

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June 26, 2025 No Comments

The Efficacy and Use of Finasteride in Women: A Systematic Review

This 2019 systematic review evaluated the use of finasteride in women for treating hair disorders such as female pattern hair loss (FPHL), frontal fibrosing alopecia (FFA), and lichen planopilaris. It included various study designs—mainly observational—with treatment doses ranging from 0.5 mg to 5 mg daily and durations spanning 6 to

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June 26, 2025 No Comments

Pantothenic Acid Deficiency as the Pathogenesis of Acne Vulgaris

This 1995 hypothesis by Dr. L.H. Leung proposes that acne vulgaris stems from a deficiency in pantothenic acid (vitamin B5), essential for synthesizing coenzyme A (CoA). CoA is crucial in fatty acid metabolism and hormone synthesis. A deficiency may impair lipid metabolism, leading to lipid accumulation in sebaceous glands and

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June 26, 2025 No Comments

The Potpourri of Family Medicine, in Sickness and in Health

This 2018 editorial in the Journal of the American Board of Family Medicine discusses diverse challenges and developments in family medicine. Topics include the management of obesity through nutrition counseling, the exploration of direct primary care models, factors contributing to physician burnout, and the critical need for family physicians in

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June 26, 2025 No Comments

Darkening of gray hair during para-amino-benzoic acid therapy

This 1950 observational report by C.J.D. Zarafonetis documented instances of gray hair darkening during para-aminobenzoic acid (PABA) therapy. Patients receiving PABA for various conditions exhibited noticeable hair repigmentation, suggesting a potential link between PABA supplementation and melanin restoration in hair follicles. While the exact mechanism remains unclear, the findings indicate

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June 26, 2025 No Comments

Optimal Support of Wound Healing: New Insights

This 2020 review by Baron, Glatz, and Proksch, published in Dermatology, reevaluates the traditional linear model of wound healing—comprising inflammation, proliferation, and remodeling—by highlighting their overlapping and concurrent nature. The authors advocate for therapeutic strategies that simultaneously address all three phases to expedite recovery and minimize complications. Dexpanthenol, a pantothenic

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June 26, 2025 No Comments

Oral Collagen Supplementation: A Systematic Review of Dermatological Applications

This 2019 systematic review analyzed 11 randomized, placebo-controlled trials involving 805 participants to assess the effects of oral collagen supplementation on skin health. The studies primarily utilized collagen hydrolysate (2.5–10 g/day over 8–24 weeks) and collagen tripeptides (3 g/day for 4–12 weeks). Findings indicated significant improvements in skin elasticity, hydration,

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June 26, 2025 No Comments