This case-control study assessed the relationship between trace element levels and androgenetic alopecia (AGA) in 116 Turkish male patients compared to 100 healthy controls. The researchers measured zinc and copper concentrations in hair, serum, and urine samples, along with body mass index (BMI). Findings revealed that patients with AGA had
This double-blind, randomized, placebo-controlled clinical trial evaluated the efficacy of low-dose zinc gluconate (200 mg/day, equivalent to ~30 mg elemental zinc) in treating patients with inflammatory acne. Participants receiving zinc gluconate showed a statistically significant reduction in the number and severity of inflammatory lesions compared to those on placebo (p
This study investigated whether baseline plasma zinc levels could predict the effectiveness of conservative therapy in males with androgenetic alopecia (AGA). Conducted in Moscow, Russia, the study included 60 male participants aged 18–55 years diagnosed with AGA. Plasma zinc concentrations were measured before initiating a 6-month conservative treatment regimen, which
This retrospective study assessed the efficacy of high-dose zinc sulfate in reversing hair loss among patients who underwent vertical gastroplasty (VG), a bariatric surgery for morbid obesity. Out of 130 patients, 47 (approximately 36%) developed diffuse hair loss despite adherence to recommended multivitamin supplementation. These patients were prescribed zinc sulfate
This study investigated the association between zinc levels in serum and hair samples of patients with chronic telogen effluvium (CTE), a non-scarring alopecia characterized by diffuse hair shedding. Conducted in Karachi, Pakistan, the study included 60 female participants aged 20–40 years, divided equally into CTE patients and healthy controls. Zinc
This 2023 study by Lalosevic et al., published in Acta Dermato-Venereologica, investigated serum zinc levels in patients with alopecia areata (AA) compared to healthy controls. The study included 100 AA patients and 100 age- and sex-matched healthy individuals. Results showed that the mean serum zinc concentration was significantly lower in
This 2012 study by Kawamura et al., published in the Journal of Clinical Investigation, investigates the effects of zinc deficiency on skin integrity and immune function in both humans and mice. The researchers observed that patients with acrodermatitis enteropathica, a genetic disorder causing zinc deficiency, exhibited severe dermatitis characterized by
This 2023 review article by Zou et al., published in Frontiers in Medicine, examines the multifaceted roles of zinc in skin health and its involvement in various dermatological conditions. Zinc is crucial for maintaining skin integrity, modulating inflammation, and supporting immune responses. The review discusses zinc’s involvement in skin disorders
This 2016 review article by Ogawa, Kawamura, and Shimada, published in Archives of Biochemistry and Biophysics, examines the critical roles of zinc in skin physiology and its involvement in various dermatological conditions. The skin is identified as the third most zinc-abundant tissue in the body, with higher concentrations in the
This 2018 review article by Ogawa et al., published in Nutrients, explores the multifaceted roles of zinc in skin physiology and its involvement in various dermatological conditions. The skin, being the third most zinc-abundant tissue, relies on zinc for numerous functions, including keratinocyte proliferation, differentiation, and immune responses. The article
