Well Referenced

Tag: Chronic inflammation

Obesity and inflammation: epidemiology, risk factors, and markers of inflammation

This 2013 review article published in International Journal of Endocrinology (DOI: 10.1155/2013/678159) explores the intricate link between obesity and chronic systemic inflammation. It details how obesity triggers an immune response in adipose tissue, leading to increased production of pro-inflammatory cytokines such as IL-6 and TNF-alpha, and acute-phase proteins like C-reactive

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June 26, 2025 No Comments

Proinflammatory cytokines, aging, and age-related diseases

This 2013 review article published in the Journal of the American Medical Directors Association (PMID: 23792036) explores the role of proinflammatory cytokines—such as IL-6, IL-1, TNF-α, and CRP—in aging and their link to age-related diseases. Chronic low-grade inflammation, termed “inflamm-aging,” is associated with increased frailty, sarcopenia, cardiovascular conditions, and neurodegenerative

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June 26, 2025 No Comments

Soluble TNFR1 has greater reproducibility than IL-6 for the assessment of chronic inflammation in older adults: the case for a new inflammatory marker in aging

This cohort study evaluated the reliability of serum biomarkers for chronic inflammation (CI) in older adults, comparing soluble tumor necrosis factor receptor 1 (sTNFR1) with interleukin-6 (IL-6). Results showed that sTNFR1 had significantly greater reproducibility over time, with intra-class correlation coefficients (ICC) of 0.95 at 6 weeks and 0.79 at

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June 26, 2025 No Comments

The Association of Anti-Inflammatory Diet Ingredients and Lifestyle Exercise with Inflammaging

This observational study examined the relationship between anti-inflammatory diet components, physical activity, and markers of chronic low-grade inflammation (“inflammaging”) in 60 Polish adults aged 65 and older. Participants with lower levels of inflammation (LGI group) had higher intake of vitamin D, a more favorable n-6/n-3 PUFA ratio, and better physical

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June 26, 2025 No Comments

The Challenge by Multiple Environmental and Biological Factors Induce Inflammation in Aging: Their Role in the Promotion of Chronic Disease

This review article explores how environmental and biological factors—such as pollution, poor nutrition, oxidative stress, and psychosocial stress—contribute to “inflammaging,” a chronic low-grade inflammatory state associated with aging. While genetic predisposition plays a minor role, the authors highlight that environmental exposures are key drivers of age-related inflammation and chronic diseases.

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June 26, 2025 No Comments

The NLRP3 Inflammasome as a Critical Actor in the Inflammaging Process

This review article discusses the role of the NLRP3 inflammasome in aging, focusing on its activation and contribution to “inflammaging” — a state of chronic low-grade inflammation associated with age-related diseases like cancer, cardiovascular disease, and neurodegenerative disorders. The NLRP3 inflammasome, activated by signals such as mitochondrial dysfunction and lysosomal

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June 26, 2025 No Comments

The role of nutrition in inflammaging

This narrative review explores the relationship between nutrition and inflammaging, the chronic low-grade inflammation associated with aging. It highlights the benefits of diets rich in whole grains, vegetables, fruits, nuts, and fish—such as the Mediterranean diet—associated with lower levels of inflammatory markers like C-reactive protein (CRP) and Tumor Necrosis Factor-α

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June 26, 2025 No Comments

Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell profiles and epigenetic ageing

This cohort study examined the trajectories of inflammatory biomarkers (C-reactive protein and interleukin-6) in individuals aged 70 to 79 and their associations with epigenetic age acceleration. Over time, low-sensitivity CRP decreased, high-sensitivity CRP remained stable, and IL-6 increased. Elevated levels of these biomarkers were associated with higher extrinsic epigenetic age

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June 26, 2025 No Comments

Anti-inflammatory effects of oral supplementation with curcumin: a systematic review and meta-analysis of randomized controlled trials

This systematic review and meta-analysis examined the anti-inflammatory effects of curcumin supplementation, incorporating data from 32 randomized controlled trials with 2,038 participants. The analysis showed significant reductions in several inflammatory markers, including C-reactive protein, interleukin-6, tumor necrosis factor-alpha, and interleukin-8, as well as an increase in interleukin-10. Curcumin supplementation also

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June 26, 2025 No Comments

Associations between a protective lifestyle behaviour score and biomarkers of chronic low-grade inflammation: a cross-sectional analysis in middle-to-older aged adults

This 2022 cohort study published in the International Journal of Obesity (DOI: 10.1038/s41366-021-01012-z, PMID: 34744162) investigates the link between a protective lifestyle behaviour (PLB) score and biomarkers of chronic low-grade inflammation in middle-to-older aged adults. The study found that individuals adhering to 4-5 protective behaviours, such as maintaining a healthy

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June 26, 2025 No Comments