This 2016 review article published in Journal of Immunology Research (DOI: 10.1155/2016/8426874, PMID: 27493973) explores the concept of inflamm-aging, which refers to chronic, low-grade inflammation that increases with age and is linked to several age-related diseases, including Alzheimer’s disease, cardiovascular diseases, type 2 diabetes, and cancer. The review discusses the
This 2022 cohort study published in the International Journal of Obesity (DOI: 10.1038/s41366-021-01012-z, PMID: 34744162) investigates the link between a protective lifestyle behaviour (PLB) score and biomarkers of chronic low-grade inflammation in middle-to-older aged adults. The study found that individuals adhering to 4-5 protective behaviours, such as maintaining a healthy
This systematic review published in Nutrients examines the association between dietary intake and biological markers of inflammation in children and adolescents. The review, which included 53 studies, found that diets rich in fruits, vegetables, and whole foods, such as the Mediterranean diet, were linked to lower levels of inflammation, while
This systematic review discusses the role of chronic inflammation in the etiology of age-related diseases, including cardiovascular, neurological, and metabolic disorders. It explores how inflammation accelerates aging and contributes to the development of various chronic diseases by activating immune pathways and releasing pro-inflammatory cytokines. The study highlights interventions targeting these
This cohort study investigates the relationship between chronic low-grade inflammation and the risk of early onset cardiometabolic multimorbidity in middle-aged and older adults. The study found that higher levels of inflammation were significantly linked to an increased risk of conditions such as hypertension, diabetes, and cardiovascular disease, with participants showing
This review discusses the role of chronic inflammation driven by the NLRP3 inflammasome in age-related conditions such as arthritis, diabetes, cardiovascular disease, and Alzheimer’s disease. It highlights how the accumulation of damage-associated molecular patterns (DAMPs) with age activates NLRP3, increasing IL-1β and IL-18 production and contributing to systemic inflammation. The
