Well Referenced

Tag: cancer stem cells

Evidence-based complementary treatment of pancreatic cancer: a review of adjunct therapies including paricalcitol, hydroxychloroquine, intravenous vitamin C, statins, metformin, curcumin, and aspirin

This 2018 review examines several adjunct therapies for pancreatic cancer that have shown promise in preclinical models and retrospective studies. Paricalcitol, a vitamin D analog, disrupts the tumor stroma, enhancing drug delivery. Hydroxychloroquine inhibits autophagy, a survival mechanism in cancer cells. Intravenous vitamin C induces cytotoxic hydrogen peroxide accumulation in

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June 26, 2025 No Comments

Cancer Prevention with Green Tea and Its Principal Constituent, EGCG: from Early Investigations to Current Focus on Human Cancer Stem Cells

This comprehensive review examines the cancer chemopreventive effects of green tea and its primary catechin, (-)-epigallocatechin gallate (EGCG), based on over three decades of research. The first section highlights key findings, including: Delayed Cancer Onset: A 10-year prospective cohort study indicated that women consuming over 10 cups of green tea

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June 26, 2025 No Comments

Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: treating cancer like an infectious disease

This article explores the potential of antibiotics that target mitochondrial function in eradicating cancer stem cells across various tumor types. The study suggests that by targeting mitochondria, these antibiotics disrupt key cellular processes in cancer stem cells, effectively reducing tumor recurrence and resistance to conventional therapies. The review proposes a

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June 26, 2025 No Comments

Anticancer Mechanisms of Salinomycin in Breast Cancer and Its Clinical Applications

This article explores the anticancer effects of salinomycin, a compound originally used as an antibiotic, in breast cancer. The study highlights salinomycin’s ability to target breast cancer stem cells, inhibit tumor growth, and induce apoptosis through multiple mechanisms, including oxidative stress and mitochondrial dysfunction. The article discusses potential clinical applications,

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June 26, 2025 No Comments

Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs

This 2017 review discusses the roles of resveratrol (RES), curcumin (CUR), and berberine (BBR) in modulating aging, cancer progression, cancer stem cells (CSCs), and microRNA (miR) expression. RES activates sirtuins (e.g., SIRT1), influencing aging and cancer-related pathways. CUR exhibits anti-inflammatory and anti-cancer properties, particularly against CSCs, by affecting gene methylation

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June 26, 2025 No Comments

Mitochondrial-Stem Cell Connection: Providing Additional Explanations for Understanding Cancer

This review introduces the Mitochondrial-Stem Cell Connection (MSCC) hypothesis, suggesting that chronic oxidative phosphorylation (OxPhos) insufficiency in stem cells leads to the formation of cancer stem cells (CSCs) and drives tumorigenesis. The hypothesis explains metabolic alterations in cancer, where cells compensate for OxPhos deficiency by upregulating glycolysis and glutaminolysis. Dysfunctional

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June 26, 2025 No Comments

Targeting the Mitochondrial-Stem Cell Connection in Cancer Treatment: A Hybrid Orthomolecular Protocol

This review article introduces the mitochondrial-stem cell connection (MSCC) theory, suggesting that cancer originates from chronic oxidative phosphorylation (OxPhos) dysfunction in stem cells, leading to the formation of cancer stem cells (CSCs). The proposed hybrid orthomolecular protocol integrates orthomolecules (e.g., vitamins C and D, zinc), repurposed drugs (e.g., ivermectin, benzimidazoles),

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June 26, 2025 No Comments