Well Referenced

Tag: cancer stem cells

Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs)

This 2017 study presents a synthetic lethal strategy combining Doxycycline and Vitamin C to eradicate cancer stem cells (CSCs). Doxycycline inhibits mitochondrial protein translation, suppressing mitochondrial DNA-encoded proteins and forcing CSCs into a glycolytic state. This metabolic inflexibility makes them susceptible to Vitamin C, which inhibits glycolysis by targeting GAPDH

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June 26, 2025 No Comments

Role of Vitamin C in Targeting Cancer Stem Cells and Cellular Plasticity

This 2023 review explores the therapeutic potential of vitamin C in targeting cancer stem cells (CSCs) and modulating cellular plasticity. It outlines vitamin C’s dose-dependent dual action: at high pharmacological doses, it acts as a pro-oxidant, generating reactive oxygen species (ROS) that selectively induce apoptosis in cancer cells; at physiological

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June 26, 2025 No Comments

Salinomycin: A new paradigm in cancer therapy

This comprehensive review discusses salinomycin, a polyether antibiotic identified as a potent agent against cancer stem cells (CSCs) and multidrug-resistant tumors. Salinomycin functions by disrupting key oncogenic signaling pathways including Wnt/β-catenin, Notch, Hedgehog, and Akt, reducing CSC viability and enhancing sensitivity to standard chemotherapeutics. Mechanistically, it induces apoptosis, autophagy, and

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June 26, 2025 No Comments

The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug

This 2018 review explores the repositioning of ivermectin, traditionally an antiparasitic agent, as a novel anticancer drug. The article highlights ivermectin’s ability to target multiple molecular pathways critical to cancer cell survival and proliferation. Mechanistically, ivermectin inhibits P-glycoprotein to overcome drug resistance, acts on chloride ion channels to induce apoptosis,

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June 26, 2025 No Comments

Pharmacological targeting of mitochondria in cancer stem cells: An ancient organelle at the crossroad of novel anti-cancer therapies

This 2019 review highlights the pivotal role of mitochondria in sustaining cancer stem cells (CSCs), focusing on their metabolic adaptability, regulation of apoptosis, and maintenance of stemness traits that contribute to tumor aggressiveness and therapy resistance. The article examines the rationale for targeting mitochondrial function as a therapeutic strategy, with

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June 26, 2025 No Comments

Cancer Prevention with Green Tea and Its Principal Constituent, EGCG: from Early Investigations to Current Focus on Human Cancer Stem Cells

This comprehensive review examines the cancer chemopreventive effects of green tea and its primary catechin, (-)-epigallocatechin gallate (EGCG), based on over three decades of research. The first section highlights key findings, including: Delayed Cancer Onset: A 10-year prospective cohort study indicated that women consuming over 10 cups of green tea

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June 26, 2025 No Comments

Combination Therapy with Vitamin C Could Eradicate Cancer Stem Cells

This review evaluates the role of high-dose vitamin C (ascorbic acid) as a complementary treatment in targeting cancer stem cells (CSCs), which are key drivers of tumor initiation, resistance, and relapse. The authors describe mechanisms by which vitamin C exerts selective cytotoxic effects on CSCs, including induction of oxidative stress

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June 26, 2025 No Comments

Epigallocatechin gallate hinders human hepatoma and colon cancer sphere formation

This 2016 study evaluates the inhibitory effects of epigallocatechin gallate (EGCG), a green tea polyphenol, on cancer stem-like cell (CSC) populations derived from human hepatoma and colon cancer cell lines. CSCs were enriched via sphere formation under nonadherent, serum-free conditions and exhibited higher expression of stemness markers, Nek2, and ATP-binding

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June 26, 2025 No Comments