Evidence-based complementary treatment of pancreatic cancer: a review of adjunct therapies including paricalcitol, hydroxychloroquine, intravenous vitamin C, statins, metformin, curcumin, and aspirin

This 2018 review examines several adjunct therapies for pancreatic cancer that have shown promise in preclinical models and retrospective studies. Paricalcitol, a vitamin D analog, disrupts the tumor stroma, enhancing drug delivery. Hydroxychloroquine inhibits autophagy, a survival mechanism in cancer cells. Intravenous vitamin C induces cytotoxic hydrogen peroxide accumulation in