Well Referenced

Tag: Bone Mineral Density

Dehydroepiandrosterone (DHEA) Supplementation in Rheumatic Diseases: A Systematic Review

The systematic review titled “Dehydroepiandrosterone (DHEA) Supplementation in Rheumatic Diseases” (Mediterranean Journal of Rheumatology, 2023, DOI: 10.31138/mjr.20230825.dd) evaluated the effectiveness of DHEA in patients with systemic lupus erythematosus (SLE), Sjögren’s syndrome (SS), rheumatoid arthritis (RA), and fibromyalgia (FM) across 21 studies. DHEA supplementation notably improved bone mineral density, reduced fatigue,

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June 26, 2025 No Comments

Dehydroepiandrosterone sulfate and postmenopausal women

The systematic review titled “Dehydroepiandrosterone (DHEA) supplementation for women in the peri- or postmenopausal phase” (Current Opinion in Obstetrics and Gynecology, 2011, PMID: 21478748) assessed the benefits and safety of DHEA supplementation in peri- and postmenopausal women. Oral DHEA supplementation showed limited and inconsistent benefits, with mild improvements in bone

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June 26, 2025 No Comments

Two to three years of hormone replacement treatment in healthy women have long-term preventive effects on bone mass and osteoporotic fractures: the PERF study

This study investigated the long-term benefits of short-term hormone replacement therapy (HRT) on bone health in postmenopausal women. A total of 347 healthy postmenopausal women participated in placebo-controlled trials, receiving either HRT or placebo for 2-3 years. Follow-up assessments conducted 5, 11, or 15 years after discontinuation showed that women

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June 26, 2025 No Comments

Sex-specific effects of dehydroepiandrosterone (DHEA) on bone mineral density and body composition: A pooled analysis of four clinical trials

This pooled analysis of four randomized controlled trials examined the sex-specific effects of dehydroepiandrosterone (DHEA) therapy on bone mineral density (BMD) and body composition in older adults. The study found that DHEA supplementation led to a 1.0% increase in lumbar spine BMD in women over 12 months, while men experienced

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June 26, 2025 No Comments

Testosterone and Bone Health in Men: A Narrative Review

This narrative review explores the role of testosterone in bone health, particularly in men with testosterone deficiency, osteopenia, or osteoporosis. The review highlights that testosterone is crucial for maintaining bone mineral density (BMD), and testosterone replacement therapy (TRT) has been shown to improve BMD in hypogonadal men. However, while TRT

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June 26, 2025 No Comments

Testosterone use in men and its effects on bone health. A systematic review and meta-analysis of randomized placebo-controlled trials

A meta-analysis published in The Journal of Clinical Endocrinology & Metabolism evaluated the effects of testosterone therapy on bone mineral density (BMD) in men by analyzing eight randomized placebo-controlled trials with 365 participants. The study found that intramuscular testosterone administration led to an 8% increase in lumbar spine BMD (95%

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June 26, 2025 No Comments

Potential anabolic effects of androgens on bone

This review examines the potential anabolic effects of androgens on bone metabolism, highlighting their role in increasing bone mineral density through both direct receptor-mediated mechanisms and indirect pathways via aromatization to estrogens. The article discusses clinical studies suggesting that androgen therapy may benefit hypogonadal men and postmenopausal women by improving

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June 26, 2025 No Comments

Estrogen and bones after menopause: a reappraisal of data and future perspectives

This review article examines the role of estrogen-based menopausal hormone therapy (MHT) in preventing postmenopausal bone loss and reducing fracture risk by exploring its dual mechanisms—suppressing osteoclast activity and enhancing osteoblast function—in a dose-dependent manner, with benefits seen even at ultra-low doses and through transdermal delivery. It discusses the clinical

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June 26, 2025 No Comments

Exogenous testosterone or testosterone with finasteride increases bone mineral density in older men with low serum testosterone

This 2004 randomized controlled trial investigated the effects of testosterone therapy, with or without finasteride, on bone mineral density (BMD) in older men with low serum testosterone levels. The study found that testosterone administration significantly increased BMD, suggesting that testosterone therapy may be beneficial for improving bone health and reducing

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June 26, 2025 No Comments

Effects of estrogen/androgen therapy on bone mineral density parameters

This review examines the effects of combined estrogen-androgen therapy on bone mineral density (BMD) in postmenopausal women, highlighting its potential to enhance bone health beyond estrogen-only treatments. Estrogen helps prevent bone resorption, while androgens may promote bone formation and muscle mass, contributing to skeletal integrity. The study suggests that this

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June 26, 2025 No Comments