This 2012 non-systematic review explores the relationship between obesity and accelerated aging, focusing on telomere dynamics in adipose tissue. Telomeres, protective DNA-protein structures at chromosome ends, shorten with each cell division, a process exacerbated by oxidative stress. The review highlights that shorter telomeres are associated with higher body mass index
This 2013 observational study evaluated the effects of long-term testosterone therapy in 261 hypogonadal men aged 32–84 years. Participants received parenteral testosterone undecanoate 1000 mg every 12 weeks over a 5-year period. Results demonstrated progressive and sustained reductions in body weight (from 100.1 ± 14.0 kg to 92.5 ± 11.2
This umbrella review analyzes the effects of polyphenols on anthropometric measures and cardiometabolic risk factors in individuals with overweight and obesity. Polyphenol supplementation led to significant reductions in body weight, body mass index (BMI), waist circumference, and fasting blood glucose levels. Additionally, improvements were seen in cholesterol levels, blood pressure,
This 2011 randomized, double-blind, placebo-controlled trial published in The American Journal of Medicine (DOI: 10.1016/j.amjmed.2010.08.005, PMID: 21187189) evaluated the effects of alpha-lipoic acid (ALA) supplementation on body weight in 360 obese adults over 20 weeks. Participants were assigned to receive either 1200 mg or 1800 mg of ALA daily, or
This 2022 cohort study published in the International Journal of Obesity (DOI: 10.1038/s41366-021-01012-z, PMID: 34744162) investigates the link between a protective lifestyle behaviour (PLB) score and biomarkers of chronic low-grade inflammation in middle-to-older aged adults. The study found that individuals adhering to 4-5 protective behaviours, such as maintaining a healthy
This cohort study evaluated clinical and metabolomic factors predicting regression from impaired fasting glucose (IFG) to normoglycemia among 491 Mexican adults at intermediate cardiometabolic risk over a 2.5-year period. Key findings showed 22.6% reverted to normal glucose levels, with younger age, lower BMI, and lower fasting glucose significantly predicting regression.
This randomized controlled trial examined the effects of choline supplementation on rapid weight loss and biochemical markers in 22 female taekwondo and judo athletes. Participants were divided into an experimental group (n=10) receiving choline supplementation for one week before competition and a control group (n=12). Choline supplementation resulted in significant
This systematic review and meta-analysis assessed the effects of L-carnitine supplementation on blood pressure (BP) in adults, including 1,412 participants from 22 randomized controlled trials. The results showed no significant reduction in systolic or diastolic blood pressure in the general population. However, a significant reduction in diastolic blood pressure was
This cross-sectional study analyzed data from 6,222 adults from NHANES (2007–2012) to investigate the relationship between the oxidative balance score (OBS)—a composite index reflecting dietary and lifestyle factors affecting oxidative stress—and thyroid function, focusing on free thyroxine (FT4) and total thyroxine (TT4). Using weighted multivariable linear regression, the study found
This cohort study evaluated the breast cancer risks associated with menopausal hormone replacement therapy (HRT) in postmenopausal women, comparing estrogen-only therapy to estrogen-progestin therapy. The study found that both estrogen-only and estrogen-progestin therapies increased breast cancer risk, with estrogen-progestin therapy showing a higher risk, particularly in women with lower BMI.
