This 2012 pooled analysis of 41 clinical trials assessed weight changes in 3,187 patients treated with pregabalin (150–600 mg/day) over one year. The majority (81.8%) maintained weight within ±7% of baseline. However, 14.5% were “delayed weight gainers,” exceeding 7% weight gain after two months, and 2.6% were “early weight gainers,”
A 12-week double-blind, randomized, placebo-controlled trial evaluated the impact of black soy peptide (BSP) supplementation on body composition in overweight and obese adults (n=80). Participants received either BSP (4.5 g/day) or placebo. The BSP group showed significant reductions in body weight, BMI, body fat mass, and body fat percentage compared
This 1998 randomized controlled trial assessed the efficacy of acarbose in 50 obese women over 12 weeks. Participants followed a 15 kcal/kg/day low-calorie diet; the intervention group received acarbose (150 mg/day for 2 weeks, then 300 mg/day for 10 weeks), while the control group received no additional treatment. Both groups
This 2011 cohort study followed 5,338 Danish men, including 1,862 classified as obese (BMI ≥31 kg/m²) at a median age of 19, over a 65-year period. The study found that obese men had a twofold higher all-cause mortality risk compared to controls (HR: 2.10; 95% CI: 1.84–2.39). Median survival was
This 6-month randomized controlled trial evaluated weight loss outcomes among 63 overweight adults (BMI 25–49.9 kg/m², aged 18–65) assigned to one of five diets: vegan, vegetarian, pesco-vegetarian, semi-vegetarian, or omnivorous. Participants attended weekly group meetings initially, transitioning to monthly sessions. No caloric restrictions were imposed. At 6 months, the vegan
This 2010 study analyzed data from the NHANES 1999–2002 survey to investigate the relationship between body burdens of selected toxic metals and obesity measures, including body mass index (BMI) and waist circumference. The researchers found that higher levels of barium and thallium were significantly associated with increased BMI and waist
This 2016 report by the International Agency for Research on Cancer (IARC) Working Group evaluated over 1,000 studies to assess the relationship between excess body fatness and cancer risk. The group concluded that the absence of excess body fatness reduces the risk of 13 cancers, including those of the colon,
This prospective cohort study evaluated 4,376 men diagnosed with clinically localized prostate cancer between 1997 and 2002, assessing the impact of BMI at diagnosis and subsequent weight changes on disease progression and mortality. Over the follow-up period, 14.6% experienced disease progression, 10.3% died from any cause, and 3.1% died from
This 2020 secondary analysis from the VITAL trial evaluated whether daily vitamin D3 supplementation (2000 IU) reduces the risk of developing advanced cancer (metastatic or fatal) among 25,871 cancer-free adults aged 50 years and older (men) and 55 years and older (women). While there was no significant reduction in total
This 2008 cross-sectional study by Healy et al. analyzed data from 168 adults (mean age 53.4 years) in the Australian Diabetes, Obesity and Lifestyle Study. Using accelerometers, researchers measured sedentary time and identified breaks as any interruption in sedentary behavior. Findings revealed that, independent of total sedentary time and moderate-to-vigorous
