Vitamin B-12 status is inversely associated with plasma homocysteine in young women with C677T and/or A1298C methylenetetrahydrofolate reductase polymorphisms

This study explored the relationship between methylenetetrahydrofolate reductase (MTHFR) polymorphisms and plasma homocysteine levels in women of reproductive age, emphasizing the role of vitamin B-12 and folate. It found that women with the C677T MTHFR genotype had significantly higher homocysteine concentrations, which were inversely associated with vitamin B-12 levels. Supplementing