Well Referenced

Tag: folate

Association of MTHFR C677T, MTHFRA1298C, and MTRRA66G Gene Polymorphisms with Hyperhomocysteinemia and Its Modulation by the Combined Effect of Vitamin B12 and Folate in Chinese Population with Hypertension

This study examined the association between MTHFR C677T, MTHFR A1298C, and MTRR A66G gene polymorphisms with hyperhomocysteinemia in a hypertensive Chinese population, and how these polymorphisms could be modulated by vitamin B12 and folate supplementation. The results showed that these genetic variations were linked to elevated homocysteine levels, and supplementation

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June 26, 2025 No Comments

Methylenetetrahydrofolate (MTHFR), the One-Carbon Cycle, and Cardiovascular Risks

This review discusses the role of methylenetetrahydrofolate reductase (MTHFR) in the one-carbon cycle, particularly focusing on the C677T polymorphism and its effect on homocysteine levels. Elevated homocysteine levels are associated with cardiovascular diseases, metabolic disorders, and inflammation. However, while the C677T polymorphism is linked to elevated homocysteine, its direct predictive

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June 26, 2025 No Comments

MTHFR isoform carriers. 5-MTHF (5-methyl tetrahydrofolate) vs folic acid: a key to pregnancy outcome: a case series

This observational study explored the effects of 5-methyl tetrahydrofolate (5-MTHF) compared to synthetic folic acid in couples with MTHFR isoform mutations (C677T and A1298C), which are linked to fertility issues and recurrent fetal loss. It found that 5-MTHF supplementation might improve pregnancy outcomes by bypassing metabolic defects caused by the

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June 26, 2025 No Comments

The methylenetetrahydrofolate reductase 677C–>T polymorphism as a modulator of a B vitamin network with major effects on homocysteine metabolism

This study examines the effect of the MTHFR 677C–>T polymorphism on homocysteine metabolism and how it interacts with B vitamin supplementation in a large cohort of adults. The study found that individuals with the TT genotype had significantly higher plasma homocysteine levels compared to those with the CC or CT

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June 26, 2025 No Comments

Vitamin B-12 status is inversely associated with plasma homocysteine in young women with C677T and/or A1298C methylenetetrahydrofolate reductase polymorphisms

This study explored the relationship between methylenetetrahydrofolate reductase (MTHFR) polymorphisms and plasma homocysteine levels in women of reproductive age, emphasizing the role of vitamin B-12 and folate. It found that women with the C677T MTHFR genotype had significantly higher homocysteine concentrations, which were inversely associated with vitamin B-12 levels. Supplementing

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June 26, 2025 No Comments

Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium

This symposium summary discusses the roles of S-adenosylmethionine (SAMe), folate, and betaine in treating alcoholic liver disease (ALD), focusing on their biochemical functions and therapeutic potential. These compounds act as methyl donors essential for hepatic transmethylation reactions, impacting homocysteine metabolism and influencing gene expression related to liver health. Deficiencies in

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June 26, 2025 No Comments

The Effects of Vitamin B in Depression

This systematic review examines the role of B-vitamin deficiencies—specifically B1, B3, B6, B9 (folate), and B12—in the development and severity of depression and cognitive decline. These vitamins are essential for neurotransmitter synthesis, methylation, homocysteine reduction, and neuronal membrane integrity. The review highlights that deficiencies in these vitamins are associated with

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June 26, 2025 No Comments

B Vitamins and the Brain: Mechanisms, Dose and Efficacy–A Review

The review article titled “B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review” by David O. Kennedy, published in Nutrients in 2016 (PMID: 26828517), examines the essential roles of the eight B-vitamins in brain function, highlighting their involvement in energy production, DNA/RNA synthesis and repair, methylation processes, and the

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June 26, 2025 No Comments