Well Referenced

Tag: one-carbon metabolism

One-Carbon Metabolism: Pulling the Strings behind Aging and Neurodegeneration

This 2022 review explores the pivotal role of one-carbon metabolism (OCM) in aging and neurodegeneration. OCM encompasses interconnected pathways like the folate and methionine cycles, crucial for DNA synthesis, methylation, redox balance, and mitochondrial function. The authors highlight how disruptions in OCM contribute to age-related diseases, including Alzheimer’s and Parkinson’s,

Read More »
June 26, 2025 No Comments

Nutrients in Energy and One-Carbon Metabolism: Learning from Metformin Users

This review explores how metformin, beyond its glucose-lowering effects, influences one-carbon metabolism by inhibiting mitochondrial complex I, leading to alterations in folate and methionine cycles. These changes can impair DNA methylation, nucleotide synthesis, and redox balance, potentially affecting cellular proliferation and aging processes. The authors discuss the implications of these

Read More »
June 26, 2025 No Comments

Vitamin B-12 status is inversely associated with plasma homocysteine in young women with C677T and/or A1298C methylenetetrahydrofolate reductase polymorphisms

This study explored the relationship between methylenetetrahydrofolate reductase (MTHFR) polymorphisms and plasma homocysteine levels in women of reproductive age, emphasizing the role of vitamin B-12 and folate. It found that women with the C677T MTHFR genotype had significantly higher homocysteine concentrations, which were inversely associated with vitamin B-12 levels. Supplementing

Read More »
June 26, 2025 No Comments