The study titled "Vascular endothelial dysfunction in aging: loss of Akt-dependent endothelial nitric oxide synthase phosphorylation and partial restoration by (R)-alpha-lipoic acid" (Biochemical Society Transactions, 2003, PMID: 14641086) examines age-related vascular endothelial dysfunction, showing a significant decline in endothelial nitric oxide synthase (eNOS) activity due to reduced phosphorylation by Akt/protein
