The 2011 review article “Glutamine Supplementation” (Annals of Intensive Care, https://doi.org/10.1186/2110-5820-1-25) evaluates the clinical significance of glutamine as a conditionally essential amino acid during critical illness, particularly in ICU patients receiving total parenteral nutrition (TPN). The review emphasizes that intravenous (IV) glutamine at 0.3–0.5 g/kg/day restores plasma levels, improves immune
The 2017 retrospective observational study titled “Safety of oral alpha-lipoic acid treatment in pregnant women,” published in the European Review for Medical and Pharmacological Sciences, investigated the safety of administering 600 mg of alpha-lipoic acid daily to 610 pregnant women for at least 7 weeks during gestation. The study found
The study titled “Vascular endothelial dysfunction in aging: loss of Akt-dependent endothelial nitric oxide synthase phosphorylation and partial restoration by (R)-alpha-lipoic acid” (Biochemical Society Transactions, 2003, PMID: 14641086) examines age-related vascular endothelial dysfunction, showing a significant decline in endothelial nitric oxide synthase (eNOS) activity due to reduced phosphorylation by Akt/protein
This randomized controlled trial examined the effects of prolonged oral supplementation with l-arginine on blood pressure and nitric oxide (NO) synthesis in preeclamptic women. Conducted with 61 participants, the study found that those receiving 3 grams of l-arginine daily for three weeks experienced significant reductions in systolic (134.2 ± 2.9
