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Tag: Akt signaling

Cotinine: a potential new therapeutic agent against Alzheimer’s disease

This review investigates cotinine, a non-toxic metabolite of nicotine, as a potential treatment for Alzheimer’s disease (AD). Preclinical studies have shown that cotinine enhances memory, reduces amyloid-beta (Aβ) pathology, and mitigates tau-related neurotoxicity in animal models. Mechanistically, cotinine appears to modulate α7 nicotinic acetylcholine receptors (α7nAChRs), activate the Akt signaling

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June 26, 2025 No Comments

Epigallocatechin gallate hinders human hepatoma and colon cancer sphere formation

This 2016 study evaluates the inhibitory effects of epigallocatechin gallate (EGCG), a green tea polyphenol, on cancer stem-like cell (CSC) populations derived from human hepatoma and colon cancer cell lines. CSCs were enriched via sphere formation under nonadherent, serum-free conditions and exhibited higher expression of stemness markers, Nek2, and ATP-binding

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June 26, 2025 No Comments

Vascular endothelial dysfunction in aging: loss of Akt-dependent endothelial nitric oxide synthase phosphorylation and partial restoration by (R)-alpha-lipoic acid

The study titled “Vascular endothelial dysfunction in aging: loss of Akt-dependent endothelial nitric oxide synthase phosphorylation and partial restoration by (R)-alpha-lipoic acid” (Biochemical Society Transactions, 2003, PMID: 14641086) examines age-related vascular endothelial dysfunction, showing a significant decline in endothelial nitric oxide synthase (eNOS) activity due to reduced phosphorylation by Akt/protein

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June 26, 2025 No Comments