Use of hormone replacement therapy and risk of venous thromboembolism: nested case-control studies using the QResearch and CPRD databases

This 2019 nested case-control study analyzed data from the QResearch and CPRD databases to assess the association between hormone replacement therapy (HRT) use and the risk of venous thromboembolism (VTE) in women aged 40–79. The study found that oral HRT, particularly combined estrogen-progestogen formulations, was associated with a significantly increased