The temporal effect of platelet-rich plasma on pain and physical function in the treatment of knee osteoarthritis: systematic review and meta-analysis of randomized controlled trials

This 2017 systematic review and meta-analysis examined the effects of intra-articular platelet-rich plasma (PRP) injections on pain and physical function in knee osteoarthritis. Fourteen randomized controlled trials were included. PRP significantly reduced pain and improved physical function at 3, 6, and 12 months compared to control treatments such as saline,