physical function Archives - Well Referenced

Improved Function With Enhanced Protein Intake per Meal: A Pilot Study of Weight Reduction in Frail, Obese Older Adults

This 2016 randomized controlled trial assessed the impact of meal-based protein enhancement on weight loss and physical function in 67 obese adults aged ≥60 with functional limitations. Participants were assigned to either a traditional weight loss diet or one with >30g protein per meal. Both groups experienced significant weight loss

June 26, 2025 No Comments

Lessons From the Testosterone Trial

This 2018 review by Snyder et al. summarizes findings from the Testosterone Trials (TTrials), a coordinated set of seven placebo-controlled, double-blind trials involving 788 men aged 65 and older with low testosterone levels. The trials assessed the effects of testosterone therapy on various health domains. Key findings include: increased sexual

June 26, 2025 No Comments

The temporal effect of platelet-rich plasma on pain and physical function in the treatment of knee osteoarthritis: systematic review and meta-analysis of randomized controlled trials

This 2017 systematic review and meta-analysis examined the effects of intra-articular platelet-rich plasma (PRP) injections on pain and physical function in knee osteoarthritis. Fourteen randomized controlled trials were included. PRP significantly reduced pain and improved physical function at 3, 6, and 12 months compared to control treatments such as saline,

June 26, 2025 No Comments

Grip strength across the life course: normative data from twelve British studies

This 2014 study pooled 60,803 observations from 49,964 participants across 12 British population studies to establish normative grip strength values from ages 4 to 90. Findings indicate that grip strength increases to a peak in early adulthood—median 51 kg in males (ages 29–39) and 31 kg in females (ages 26–42)—followed

June 26, 2025 No Comments

Effectiveness of topical ozonated oil in severe osteoarthritis: A randomised, triple-blinded, placebo-controlled study

This randomized, triple-blinded, placebo-controlled trial assessed the effectiveness of topical ozonated oil in treating severe osteoarthritis (OA). The study involved 60 patients who applied ozonated oil for four weeks, resulting in significant improvements in pain, stiffness, and physical function, as measured by WOMAC and VAS scores. The ozonated oil group

June 26, 2025 No Comments

Ginseng and health outcomes: an umbrella review

This umbrella review analyzed 19 meta-analyses to assess the health benefits of ginseng supplementation, which showed improvements in various conditions such as fatigue, physical function, sexual function, menopausal symptoms, metabolic indicators, inflammatory markers, unstable angina, and respiratory diseases. While ginseng exhibited positive effects compared to placebo controls, the review highlighted

June 26, 2025 No Comments

Hormone replacement therapy and physical function in healthy older men. Time to talk hormones?

This review discusses the potential benefits of hormone replacement therapy (HRT), particularly testosterone and growth hormone (GH), in maintaining physical function in older men, especially those suffering from age-related declines in muscle mass and strength (sarcopenia). It highlights that while exercise is important, it may not be sufficient for older

June 26, 2025 No Comments

Testosterone dose-response relationships in hysterectomized women with or without oophorectomy: effects on sexual function, body composition, muscle performance and physical function in a randomized trial

Testosterone therapy in hysterectomized postmenopausal women was studied in a randomized controlled trial examining its effects on sexual function, body composition, muscle performance, and physical function over 24 weeks. 71 participants received weekly intramuscular injections of placebo or testosterone enanthate (3, 6.25, 12.5, or 25 mg). The results showed dose-dependent

June 26, 2025 No Comments

Basal growth hormone concentration increased following a weight loss focused dietary intervention in older overweight and obese women

This study investigated how dietary and exercise interventions affected growth hormone (GH) levels in older adults, finding a significant increase in GH levels in women following weight loss, with no changes in men. The intervention aimed for a weight loss of ≥5%, with exercise groups performing 3 days of walking

June 26, 2025 No Comments

Tag: physical function