Rapamycin Archives - Well Referenced

Formulation and characterization of a 0.1% rapamycin cream for the treatment of Tuberous Sclerosis Complex-related angiofibromas

This study details the development of a 0.1% rapamycin (sirolimus) cream aimed at treating facial angiofibromas associated with Tuberous Sclerosis Complex (TSC). The formulation process involved dissolving rapamycin in Transcutol®, a solvent known for enhancing skin penetration, followed by incorporation into an oil-in-water cream base (Excipial Hydrocrème®). Stability assessments demonstrated

June 26, 2025 No Comments

Of Mice and Men: The Benefits of Caloric Restriction, Exercise, and Mimetics

This review explores the physiological and molecular effects of caloric restriction (CR), exercise, and pharmacological mimetics on aging and metabolic health. CR has been shown to extend both mean and maximum lifespan in animal models by activating stress response pathways and enhancing mitochondrial function. Exercise primarily improves healthspan, delaying the

June 26, 2025 No Comments

Old wine in new bottles: Drug repurposing in oncology

This 2019 review explores drug repurposing as a cost-effective and time-saving strategy in oncology, highlighting its potential to expedite the development of cancer treatments. The authors discuss several non-oncologic drugs—such as artesunate, aspirin, cimetidine, doxycycline, ivermectin, metformin, rapamycin, and thalidomide—that exhibit anticancer properties through mechanisms like apoptosis induction, angiogenesis inhibition,

June 26, 2025 No Comments

Increasing healthy lifespan by suppressing aging in our lifetime: preliminary proposal

This 2010 article by Mikhail V. Blagosklonny proposes a translational framework to extend healthy lifespan by pharmacologically suppressing aging. The author introduces the concept of “post-aging syndrome,” where age-related diseases are delayed or prevented through targeted interventions. Central to this approach is the inhibition of the mTOR pathway, which is

June 26, 2025 No Comments

Biology of Healthy Aging and Longevity

This review explores the complex biological processes underlying healthy aging and extended lifespan. It emphasizes the roles of genetic and environmental factors, highlighting key pathways such as insulin/IGF-1, mTOR, AMPK, and sirtuins in regulating aging. The article discusses mechanisms like oxidative stress, mitochondrial dysfunction, cellular senescence, and stem cell exhaustion

June 26, 2025 No Comments

Are Menopause, Aging and Prostate Cancer Diseases?

This 2023 article by Mikhail V. Blagosklonny explores the classification of menopause, aging, and prostate cancer as diseases through the lens of the hyperfunction theory of aging. While prostate cancer is universally recognized as a disease, the author argues that menopause, despite being a natural process, is also a disease

June 26, 2025 No Comments

Stimulation of Hair Growth by Small Molecules that Activate Autophagy

This 2019 study published in Cell Reports investigates the role of autophagy activation in promoting hair growth. Researchers found that compounds such as rapamycin, metformin, α-ketoglutarate (α-KG), and α-ketobutyrate (α-KB) stimulate the transition of hair follicles from the telogen (resting) to the anagen (growth) phase by activating autophagy. Inhibition of

June 26, 2025 No Comments

Rapamycin and Alzheimer’s Disease: Time for a Clinical Trial?

This 2019 opinion article by Matt Kaeberlein and Veronica Galvan advocates for initiating clinical trials to assess rapamycin’s efficacy in treating Alzheimer’s disease (AD). Despite compelling preclinical evidence demonstrating rapamycin’s benefits in animal models—such as reducing amyloid-beta and tau pathology, improving cognitive function, and enhancing synaptic plasticity—no human trials had

June 26, 2025 No Comments

Rapamycin and Alzheimer Disease: A Double-Edged Sword?

This 2019 opinion article by Carosi and Sargeant evaluates the dualistic role of rapamycin in Alzheimer’s disease (AD) treatment. While early intervention with rapamycin in animal models has shown reductions in amyloid-beta and tau pathology, the authors caution against its use in later stages of AD. They argue that in

June 26, 2025 No Comments

The Role of the Mammalian Target of Rapamycin (mTOR) in Pulmonary Fibrosis

This 2018 review examines the role of the PI3K/AKT/mTOR pathway in the development and progression of pulmonary fibrosis, particularly idiopathic pulmonary fibrosis (IPF) and radiation-induced pulmonary fibrosis (RIPF). It outlines how mTOR dysregulation contributes to fibroblast proliferation, suppression of autophagy, chronic inflammation, and epithelial-mesenchymal transition (EMT), all of which drive

June 26, 2025 No Comments

Tag: Rapamycin