This review article explores the cardiovascular benefits of plant-derived polyphenols, including kaempferol, quercetin, and resveratrol, highlighting their antioxidant, anti-inflammatory, and vasodilatory properties. These compounds work by reducing oxidative stress, improving endothelial function via nitric oxide production, and preventing LDL oxidation, which together help mitigate atherosclerosis, hypertension, and other cardiovascular diseases.