Well Referenced

Tag: polyphenols

Hibiscus sabdariffa extract inhibits obesity and fat accumulation, and improves liver steatosis in humans

This 2014 randomized controlled trial assessed the effects of Hibiscus sabdariffa extract (HSE) on obesity and liver steatosis in overweight individuals (BMI ≥27). Over 12 weeks, participants consuming HSE exhibited significant reductions in body weight, BMI, body fat, waist-to-hip ratio, and serum free fatty acids compared to controls. Imaging studies

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June 26, 2025 No Comments

The Role of Natural Antioxidants Against Reactive Oxygen Species Produced by Cadmium Toxicity: A Review

This review article explores the mechanisms by which cadmium (Cd) induces oxidative stress and evaluates the potential protective roles of natural antioxidants. Cd exposure disrupts cellular redox homeostasis through the excessive generation of reactive oxygen species (ROS), leading to damage in lipids, proteins, and DNA. The review highlights natural antioxidant

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June 26, 2025 No Comments

The Role of Antioxidants in Skin Cancer Prevention and Treatment

This 2014 review evaluates the role of antioxidants in counteracting oxidative stress caused by ultraviolet radiation (UVR), a key factor in skin carcinogenesis. It explains how UVR leads to the generation of reactive oxygen species (ROS) that damage DNA, proteins, and lipids, accelerating skin aging and promoting cancer. The body’s

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June 26, 2025 No Comments

Dietary Factors and Prostate Cancer Development, Progression, and Reduction

This 2021 review examines the role of various dietary factors in the development, progression, and potential reduction of prostate cancer (PCa). High intake of red and processed meats, saturated fats, and dairy products is associated with increased PCa risk. Conversely, diets high in fruits, vegetables, legumes, and whole grains, especially

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June 26, 2025 No Comments

Impaired Nicotinamide Adenine Dinucleotide (NAD⁺) Metabolism in Diabetes and Diabetic Tissues: Implications for Nicotinamide-Related Compound Treatment

This 2020 review explores how diabetes disrupts NAD⁺ metabolism, leading to reduced NAD⁺/NADH ratios (pseudohypoxia) due to increased substrate oxidation. In type 1 diabetes, NAD⁺ depletion is driven by poly(ADP-ribose) polymerase (PARP) activation, while in type 2 diabetes, decreased AMP-activated protein kinase (AMPK) activity impairs NAD⁺ biosynthesis via downregulation of

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June 26, 2025 No Comments

Dietary approaches that delay age-related diseases

This 2006 review outlines evidence linking dietary patterns to the prevention of age-related diseases. It emphasizes that diets low in calories and saturated fats, and high in whole grains, legumes, fruits, and vegetables, can delay the onset of conditions such as cardiovascular disease, type 2 diabetes, certain cancers, osteoporosis, and

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June 26, 2025 No Comments

Effects of Polyphenol-Rich Foods on Human Health

This editorial discusses the health benefits of polyphenol-rich foods, which are associated with a reduced risk of chronic diseases such as cardiovascular diseases, certain cancers, and neurodegenerative disorders. Polyphenols, known for their antioxidant and chemopreventive properties, exert protective effects through antioxidant activities and modulation of cellular pathways involved in inflammation

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June 26, 2025 No Comments

Harnessing the Power of Polyphenols: A New Frontier in Disease Prevention and Therapy

This systematic review explores the health benefits of polyphenols, which are abundant in foods like fruits, vegetables, tea, and coffee. Polyphenols have demonstrated antioxidant properties and have been shown to prevent and manage chronic diseases such as obesity, atherosclerosis, diabetes, hypertension, cancer, and neurological disorders. The review discusses the mechanisms

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June 26, 2025 No Comments

Plant Polyphenols and Their Potential Benefits on Cardiovascular Health: A Review

This review article explores the cardiovascular benefits of plant-derived polyphenols, including kaempferol, quercetin, and resveratrol, highlighting their antioxidant, anti-inflammatory, and vasodilatory properties. These compounds work by reducing oxidative stress, improving endothelial function via nitric oxide production, and preventing LDL oxidation, which together help mitigate atherosclerosis, hypertension, and other cardiovascular diseases.

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June 26, 2025 No Comments

Anthropometric and cardiometabolic effects of polyphenols in people with overweight and obesity: an umbrella review

This umbrella review analyzes the effects of polyphenols on anthropometric measures and cardiometabolic risk factors in individuals with overweight and obesity. Polyphenol supplementation led to significant reductions in body weight, body mass index (BMI), waist circumference, and fasting blood glucose levels. Additionally, improvements were seen in cholesterol levels, blood pressure,

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June 26, 2025 No Comments