Well Referenced

Tag: Hypertension

Metabolic sequelae of β-blocker therapy: weighing in on the obesity epidemic?

This 2011 study by Lee et al. investigates the metabolic effects of chronic β-blocker therapy. The research comprises a mechanistic study comparing energy expenditure (EE), diet-induced thermogenesis, and habitual activity between β-blocker-treated individuals and matched controls, alongside cross-sectional analyses of body weight, BMI, and waist circumference in patients from diabetes

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June 26, 2025 No Comments

Effect of Monacolin K and CoQ10 Supplementation in Hypertensive and Hypercholesterolemic Subjects with Metabolic Syndrome

This study evaluated the effects of a combined supplementation of Monacolin K (10 mg/day) and Coenzyme Q10 (30 mg/day) over 8 weeks in 40 patients with metabolic syndrome characterized by hypertension and hypercholesterolemia. The intervention led to significant reductions in systolic and diastolic blood pressure, total cholesterol, LDL cholesterol, and

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June 26, 2025 No Comments

Status Report on Hypertension in Africa—Consultative Review for the 6th Session of the African Union Conference of Ministers of Health on NCDs

This 2013 review highlights the escalating burden of hypertension in Africa, noting that average blood pressures are now higher in Africa than in Europe and the USA. The prevalence is increasing among poorer populations, challenging the notion that hypertension is a disease of affluence. Hypertension is identified as the leading

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June 26, 2025 No Comments

The Impact of Lipoic Acid on Endothelial Function and Proteinuria in Quinapril-Treated Diabetic Patients with Stage I Hypertension: Results from the QUALITY Study

This 2012 randomized, double-blind, crossover study investigated the effects of α-lipoic acid (ALA) on endothelial function and proteinuria in 40 diabetic patients with stage I hypertension receiving quinapril 40 mg/day. Participants were treated for 8 weeks with either quinapril alone or quinapril plus ALA 600 mg/day. Results showed that the

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June 26, 2025 No Comments

Effect of Short-Term Supplementation of Potassium Chloride and Potassium Citrate on Blood Pressure in Hypertensives

This 2005 randomized crossover trial by He et al. assessed the effects of potassium chloride (KCl) and potassium citrate (K-citrate) supplementation on blood pressure in 14 hypertensive individuals. Participants received 96 mmol/day of either KCl or K-citrate for one week each. Both supplements significantly reduced systolic and diastolic blood pressure

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June 26, 2025 No Comments

The Association Between Environmental Cadmium Exposure, Blood Pressure, and Hypertension: A Systematic Review and Meta-Analysis

This systematic review and meta-analysis evaluated the relationship between environmental cadmium (Cd) exposure and blood pressure (BP)/hypertension (HTN) in general populations. The study included literature published between 2000 and April 2021, assessing Cd levels in blood, urine, and hair samples. Findings indicated a positive association between Cd exposure and increased

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June 26, 2025 No Comments

Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study

This phase 2, double-blind, placebo-controlled trial evaluated the effects of daily dietary nitrate supplementation on blood pressure in 68 hypertensive patients over four weeks. Participants received either 250 mL of nitrate-rich beetroot juice or nitrate-depleted placebo juice daily. The study found significant reductions in clinic, ambulatory, and home blood pressure

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June 26, 2025 No Comments

Lead nephropathy, gout, and hypertension

This 1993 review by V. Batuman highlights the persistent issue of lead nephropathy despite modern exposure standards. Lead nephropathy is characterized as a chronic tubulointerstitial renal disease presenting with modest proteinuria, hyperuricemia, gout, and hypertension. The study emphasizes the utility of the EDTA (calcium disodium edetate) lead mobilization test and

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June 26, 2025 No Comments