This 2021 preclinical study evaluated the impact of intraperitoneal ozone therapy on erectile function and nitric oxide synthase (NOS) expression in streptozotocin-induced diabetic rats. Eighteen rats were divided into control, diabetes mellitus (DM), and DM + ozone therapy groups. After two weeks of ozone treatment, the DM + ozone group
This 2012 review article examines the role of carotenoids—fat-soluble pigments found in fruits and vegetables—in cardiovascular health. Carotenoids, such as beta-carotene, lycopene, lutein, and zeaxanthin, possess antioxidant properties that can neutralize reactive oxygen species (ROS), thereby reducing oxidative stress—a key factor in atherosclerosis development. The review highlights that carotenoids may
This randomized, double-blind, placebo-controlled crossover trial examined the impact of 6 weeks of MitoQ (20 mg/day) supplementation on vascular function in 20 healthy older adults aged 60–79 years with baseline endothelial dysfunction. MitoQ significantly enhanced brachial artery flow-mediated dilation (FMD) by 42% relative to placebo, indicating improved endothelial function. Among
This 2012 randomized, double-blind, crossover study investigated the effects of α-lipoic acid (ALA) on endothelial function and proteinuria in 40 diabetic patients with stage I hypertension receiving quinapril 40 mg/day. Participants were treated for 8 weeks with either quinapril alone or quinapril plus ALA 600 mg/day. Results showed that the
This phase 2, double-blind, placebo-controlled trial evaluated the effects of daily dietary nitrate supplementation on blood pressure in 68 hypertensive patients over four weeks. Participants received either 250 mL of nitrate-rich beetroot juice or nitrate-depleted placebo juice daily. The study found significant reductions in clinic, ambulatory, and home blood pressure
This comprehensive review examines the influence of vitamins A, B12, C, D, E, and K on arterial stiffness, a key predictor of cardiovascular morbidity and mortality. The authors discuss mechanisms by which these vitamins may reduce arterial stiffness, including antiatherogenic effects, improvement of endothelial function (A, C, D, E), modulation
This review article explores the cardiovascular benefits of plant-derived polyphenols, including kaempferol, quercetin, and resveratrol, highlighting their antioxidant, anti-inflammatory, and vasodilatory properties. These compounds work by reducing oxidative stress, improving endothelial function via nitric oxide production, and preventing LDL oxidation, which together help mitigate atherosclerosis, hypertension, and other cardiovascular diseases.
This review explores the cardiovascular benefits of resveratrol (RES), detailing its molecular mechanisms, including its effects on cell longevity, energy metabolism in heart cells, and cardiac remodeling. RES’s anti-inflammatory and antioxidant properties improve endothelial function, reduce oxidative stress, and potentially offer therapeutic benefits in cardiovascular diseases, including COVID-19-related cardiovascular complications.
This review article explores the cardiovascular protective effects of dietary polyphenols, which are abundant in foods such as grapes, berries, dark chocolate, and tea. These polyphenols have demonstrated antioxidant properties that help mitigate oxidative stress, a key contributor to cardiovascular diseases. The review discusses various studies showing that polyphenols can
This review article explores the beneficial effects of resveratrol, focusing on its potential mechanisms in cardiovascular conditions. It highlights resveratrol’s ability to improve endothelial function, reduce oxidative stress, and modulate lipid metabolism, which are critical factors in cardiovascular health. The review suggests that resveratrol may offer therapeutic benefits by activating
