Well Referenced

Tag: quercetin

Phytochemicals and regulation of the adipocyte life cycle

This 2008 review article explores the role of various dietary phytochemicals in modulating different stages of the adipocyte life cycle, including preadipocyte proliferation, differentiation (adipogenesis), lipid accumulation, and apoptosis. Compounds such as genistein, conjugated linoleic acid (CLA), docosahexaenoic acid (DHA), epigallocatechin gallate (EGCG), quercetin, resveratrol, and ajoene have been shown

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June 26, 2025 No Comments

Health supplements for allergic rhinitis: A mixed-methods systematic review

This 2020 mixed-methods systematic review assessed the efficacy and safety of various health supplements in managing allergic rhinitis. Analyzing 48 randomized controlled trials and 10 observational studies, the review found promising evidence for single supplements such as apple polyphenols, tomato extract, spirulina, chlorophyll c2, honey, conjugated linoleic acid, methylsulfonylmethane (MSM),

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June 26, 2025 No Comments

Novel Nutraceutical Compounds in Alzheimer Prevention

This review highlights the potential of nutraceuticals—bioactive compounds derived from food sources—in preventing Alzheimer’s disease (AD). The authors discuss how certain nutraceuticals, such as quercetin, biocurcumin, rosmarinic acid, Andean shilajit, anthocyanidins, and hydroxytyrosol, exhibit antioxidant, anti-inflammatory, and anti-amyloid properties. These compounds may interfere with AD pathogenesis by reducing oxidative stress,

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June 26, 2025 No Comments

Molecular mechanisms underlying protective role of quercetin in attenuating Alzheimer’s disease

This review explores quercetin’s neuroprotective mechanisms in Alzheimer’s disease (AD). Quercetin, a flavonoid with antioxidant properties, mitigates oxidative stress by scavenging reactive oxygen species and modulates signaling pathways such as Nrf2, JNK, MAPK, and PI3K/Akt. These actions reduce neuroinflammation, inhibit amyloid-beta aggregation, and prevent tau hyperphosphorylation. Additionally, quercetin influences gene

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June 26, 2025 No Comments

Plant Polyphenols and Their Potential Benefits on Cardiovascular Health: A Review

This review article explores the cardiovascular benefits of plant-derived polyphenols, including kaempferol, quercetin, and resveratrol, highlighting their antioxidant, anti-inflammatory, and vasodilatory properties. These compounds work by reducing oxidative stress, improving endothelial function via nitric oxide production, and preventing LDL oxidation, which together help mitigate atherosclerosis, hypertension, and other cardiovascular diseases.

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June 26, 2025 No Comments

Quercetin as a Lyn kinase inhibitor inhibits IgE-mediated allergic conjunctivitis

This study evaluated the effects of quercetin, a plant-derived flavonoid, on IgE-mediated allergic conjunctivitis using both in vitro cell cultures and in vivo mouse models. Quercetin was shown to significantly reduce mast cell degranulation and the release of histamine and inflammatory mediators, resulting in marked improvements in allergic conjunctivitis symptoms.

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June 26, 2025 No Comments

Quercetin inhibits expression of inflammatory cytokines through attenuation of NF-kappaB and p38 MAPK in HMC-1 human mast cell line

This in vitro study investigated the effects of quercetin on human mast cells (HMC-1) stimulated to produce inflammatory cytokines. The researchers found that quercetin significantly inhibited the expression and production of TNF-α, IL-1β, IL-6, and IL-8 by attenuating the activation of NF-kappaB and p38 MAPK pathways—two major regulators of inflammation.

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June 26, 2025 No Comments

Quercetin inhibits Mrgprx2-induced pseudo-allergic reaction via PLCγ-IP3R related Ca2+ fluctuations

This study explored quercetin’s effects on pseudo-allergic reactions, particularly those mediated by the Mrgprx2 receptor in mast cells. In vivo, quercetin reduced Evans blue leakage and paw swelling, indicating suppressed allergic responses. In vitro, it inhibited calcium influx and mast cell degranulation by disrupting the PLCγ-IP3R signaling pathway. Molecular docking

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June 26, 2025 No Comments

Quercetin inhibits transcriptional up-regulation of histamine H1 receptor via suppressing protein kinase C-δ/extracellular signal-regulated kinase/poly(ADP-ribose) polymerase-1 signaling pathway in HeLa cells

This study investigated quercetin’s ability to modulate histamine H1 receptor (H1R) gene expression in HeLa cells and its effects on allergy-like symptoms in TDI-sensitized rats. Quercetin suppressed histamine- and PMA-induced up-regulation of H1R by inhibiting PKC-δ activation and its translocation, reducing allergy-like symptoms in rats. In vivo, it also decreased

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June 26, 2025 No Comments