This 2015 study investigated the anti-inflammatory effects of methylene blue (MB) in a rat model of acetic acid-induced colitis. Eighty male Sprague-Dawley rats were divided into four groups: control, control + MB, colitis, and colitis + MB. Colitis was induced via rectal administration of acetic acid. MB treatment significantly reduced
This 2024 review article explores the role of low-dose colchicine (0.5 mg daily) as an anti-inflammatory therapy in reducing adverse cardiovascular events following acute coronary syndrome (ACS). Colchicine exerts its effects by inhibiting microtubule polymerization, thereby reducing leukocyte activation and inflammatory responses implicated in atherosclerotic plaque destabilization. Clinical trials, including
This 2019 narrative review titled “Ultrasonography for Oxygen-Ozone Therapy in Musculoskeletal Diseases” (Medical Gas Research, DOI: [10.4103/2045-9912.254638]*) discusses how using ultrasonography significantly enhances the precision, safety, and effectiveness of oxygen-ozone therapy in musculoskeletal conditions such as tendonitis, arthritis, and spinal disorders. Oxygen-ozone therapy offers analgesic, anti-inflammatory, antioxidant, and immunomodulatory effects,
This 2024 comprehensive review titled “Ozone therapy in musculoskeletal medicine: a comprehensive review” (European Journal of Medical Research, DOI: [10.1186/s40001-024-01976-4*) evaluated the use of ozone therapy in treating musculoskeletal conditions such as osteoarthritis, lumbar disc herniation, tendinopathies, and myofascial pain syndromes. The review described ozone’s mechanisms—enhancing oxygen metabolism, modulating oxidative
This 2019 review published in International Journal of Molecular Sciences (DOI: 10.3390/ijms20051223, PMID: 30862067) explores the dual role of melatonin in aging and inflammation. Melatonin’s secretion decreases with age, leading to immune dysfunction and inflammatory diseases. The review discusses melatonin’s ability to both promote and suppress inflammation depending on the
This systematic review discusses the role of chronic inflammation in the etiology of age-related diseases, including cardiovascular, neurological, and metabolic disorders. It explores how inflammation accelerates aging and contributes to the development of various chronic diseases by activating immune pathways and releasing pro-inflammatory cytokines. The study highlights interventions targeting these
