Neurochemical effects of the R form of α-lipoic acid and its neuroprotective mechanism in cellular models of Parkinson’s disease

This 2017 study investigated the neuroprotective effects of R-α-lipoic acid (RLA) in cellular models of Parkinson's disease (PD) induced by 6-hydroxydopamine (6-OHDA) and MPTP. RLA treatment enhanced cell viability, reduced apoptosis, and decreased intracellular reactive oxygen species (ROS) levels. It also restored dopamine levels and reduced α-synuclein accumulation. Additionally, RLA