Methylenetetrahydrofolate reductase 677C–>T genotype modulates homocysteine responses to a folate-rich diet or a low-dose folic acid supplement: a randomized controlled trial

This study explored the impact of the methylenetetrahydrofolate reductase (MTHFR) 677C-->T genotype on plasma folate and homocysteine levels following dietary interventions, such as a folate-rich diet or low-dose folic acid supplementation. A total of 126 healthy participants (42 with TT, 42 with CT, and 42 with CC genotypes) underwent three