Well Referenced

Tag: personalized medicine

Precision Obesity Treatments Including Pharmacogenetic and Nutrigenetic Approaches

This 2016 review explores the integration of pharmacogenetic and nutrigenetic strategies into obesity management, emphasizing personalized treatment plans based on genetic profiles. It discusses the efficacy of FDA-approved anti-obesity drugs—such as orlistat, lorcaserin, liraglutide, phentermine/topiramate, and bupropion/naltrexone—and highlights how genetic variations can influence individual responses to these medications. The review

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June 26, 2025 No Comments

Trying to Solve the Puzzle of the Interaction of Ascorbic Acid and Iron: Redox, Chelation and Therapeutic Implications

This 2020 review explores the complex interplay between ascorbic acid (vitamin C) and iron, emphasizing their redox and chelation dynamics with significant clinical implications. Vitamin C enhances iron absorption by reducing ferric (Fe³⁺) to ferrous (Fe²⁺) iron, facilitating uptake. However, this reduction can also catalyze the Fenton reaction, generating reactive

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June 26, 2025 No Comments

An Online Survey of Hypothyroid Patients Demonstrates Prominent Dissatisfaction

This 2018 cross-sectional online survey assessed treatment satisfaction among 12,146 hypothyroid patients in the U.S. Participants reported their experiences with levothyroxine (LT4) monotherapy, LT4 plus liothyronine (LT3) combination therapy, or desiccated thyroid extract (DTE). Patients using DTE reported significantly greater satisfaction with their treatment, including better outcomes in weight management,

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June 26, 2025 No Comments

Personalization of multiple sclerosis treatments: using the chelation therapy approach

This 2023 study by Vezzoli et al. investigates the efficacy of combining calcium disodium EDTA (CaNa₂EDTA) chelation therapy with antioxidant micronutrient supplementation in patients with multiple sclerosis (MS). The research involved 20 MS patients and 20 healthy controls, assessing oxidative stress markers, inflammatory cytokines, and nitric oxide metabolites. Post-treatment results

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June 26, 2025 No Comments

Empiric therapy for kidney stones

This 2019 review by David S. Goldfarb advocates for empiric therapy in managing kidney stones, particularly in settings where advanced diagnostic tools like 24-hour urine analysis and genetic testing are unavailable. The article emphasizes that increased fluid intake, dietary modifications, and pharmacologic interventions such as potassium citrate and thiazide diuretics

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June 26, 2025 No Comments

Prostate Cancer Detection and Prognosis: From Prostate Specific Antigen (PSA) to Exosomal Biomarkers

This 2014 review addresses the shortcomings of PSA as a biomarker for prostate cancer, including low specificity and the resulting overdiagnosis and overtreatment. It explores the promise of exosomal biomarkers—extracellular vesicles containing nucleic acids and proteins—as more precise, non-invasive diagnostic and prognostic tools. Exosomes isolated from blood, urine, and other

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June 26, 2025 No Comments

Prostate Cancer Review: Genetics, Diagnosis, Treatment Options, and Alternative Approach

This 2022 comprehensive review discusses the genetic factors, diagnostic methods, current treatments, and emerging alternative therapies for prostate cancer. It highlights the role of genetic mutations in disease onset and progression, standard diagnostic tools like PSA testing and biopsies, and conventional treatments including surgery, radiotherapy, and hormone therapy. The review

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June 26, 2025 No Comments

Cancer DNA in the Circulation: The Liquid Biopsy

This article discusses the emerging field of liquid biopsy, focusing on the detection of circulating tumor DNA (ctDNA) in the bloodstream as a non-invasive method for cancer diagnosis and monitoring. The review highlights the advantages of liquid biopsy over traditional tissue biopsies, including its ability to capture tumor heterogeneity, monitor

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June 26, 2025 No Comments

Evidence on Statins, Omega-3, and Prostate Cancer: A Narrative Review

This 2022 narrative review examines the associations between statin use, omega-3 fatty acid intake, and prostate cancer (PCa) risk and progression. Statins have been linked to a reduced incidence of advanced PCa and may decrease the risk of biochemical recurrence (BCR) post-treatment. However, their impact on BCR and PCa progression

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June 26, 2025 No Comments