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Tag: folic acid supplementation

Homocysteine lowering by folate-rich diet or pharmacological supplementations in subjects with moderate hyperhomocysteinemia

This study evaluated the effects of a folate-rich diet and folic acid supplementation (5-MTHF and folic acid) on homocysteine levels in individuals with moderate hyperhomocysteinemia, also considering MTHFR C677T genotype. The results demonstrated that both the diet and supplementation led to significant reductions in homocysteine levels, with greater reductions observed

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June 26, 2025 No Comments

Methylenetetrahydrofolate reductase 677C–>T genotype modulates homocysteine responses to a folate-rich diet or a low-dose folic acid supplement: a randomized controlled trial

This study explored the impact of the methylenetetrahydrofolate reductase (MTHFR) 677C–>T genotype on plasma folate and homocysteine levels following dietary interventions, such as a folate-rich diet or low-dose folic acid supplementation. A total of 126 healthy participants (42 with TT, 42 with CT, and 42 with CC genotypes) underwent three

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June 26, 2025 No Comments

Quantification of multi-pathway metabolites related to folate metabolism and application in natural population with MTHFR C677T polymorphism

This study analyzed the impact of the MTHFR C677T polymorphism on folate metabolism and its effects on health. Using liquid chromatography-tandem mass spectrometry (LC-MS/MS), the study identified changes in folate-related metabolites in individuals with this genetic variant, particularly in 5-methyltetrahydrofolate levels and metabolites involved in DNA synthesis. The findings highlight

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June 26, 2025 No Comments