This study demonstrates that low-dose metformin treatment delays cellular senescence in human diploid fibroblasts and mesenchymal stem cells by upregulating glutathione peroxidase 7 (GPx7), an endoplasmic reticulum-localized antioxidant enzyme. Metformin enhances nuclear translocation of Nrf2, a transcription factor that binds to antioxidant response elements in the GPX7 promoter, thereby increasing
