Well Referenced

Tag: Antioxidant Response

Ozone: A Multifaceted Molecule with Unexpected Therapeutic Activity

This 2016 review by Zanardi et al. explores the dual nature of ozone (O₃) as both a potent oxidant and a therapeutic agent. The authors discuss how, at controlled doses, ozone can stimulate beneficial biological responses, including the activation of antioxidant systems and modulation of the immune response. The review

Read More »
June 26, 2025 No Comments

Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7

This study demonstrates that low-dose metformin treatment delays cellular senescence in human diploid fibroblasts and mesenchymal stem cells by upregulating glutathione peroxidase 7 (GPx7), an endoplasmic reticulum-localized antioxidant enzyme. Metformin enhances nuclear translocation of Nrf2, a transcription factor that binds to antioxidant response elements in the GPX7 promoter, thereby increasing

Read More »
June 26, 2025 No Comments