This 2022 review examines the complex and context-dependent roles of Glutathione Peroxidase 1 (GPX1), a selenium-dependent antioxidant enzyme, in cancer. GPX1 reduces hydrogen peroxide and lipid peroxides, thereby mitigating oxidative stress, which can influence both tumor suppression and progression. The review highlights the impact of the Pro198Leu (rs1050450 C>T) polymorphism,
