This 2022 review examines the complex and context-dependent roles of Glutathione Peroxidase 1 (GPX1), a selenium-dependent antioxidant enzyme, in cancer. GPX1 reduces hydrogen peroxide and lipid peroxides, thereby mitigating oxidative stress, which can influence both tumor suppression and progression. The review highlights the impact of the Pro198Leu (rs1050450 C>T) polymorphism,
This review discusses the potential benefits of methionine restriction as a therapeutic approach in cancer treatment. It explains how reducing methionine intake inhibits cancer cell growth by limiting methylation, polyamine synthesis, and glutathione formation, all critical processes for tumor growth. Methionine restriction may enhance the efficacy of chemotherapy and offers
The article “Glutathione in Cancer Biology and Therapy” examines the multifaceted role of glutathione (GSH) in cancer, emphasizing its impact on cell growth, DNA synthesis, mutagenic processes, and resistance to chemotherapy and radiation. Elevated levels of GSH in many tumors contribute to drug resistance and survival during oxidative and nitrosative
