Well Referenced

Tag: chemoresistance

Therapeutic Effects of Artesunate in Hepatocellular Carcinoma: Repurposing an Ancient Antimalarial Agent

This preclinical study investigated the anticancer properties of artesunate, a semisynthetic artemisinin derivative, in hepatocellular carcinoma (HCC). Artesunate significantly inhibited cell viability and induced caspase-3-mediated apoptosis in HCC cell lines (HepG2, BWTG3), with more pronounced effects under hypoxic conditions. It also suppressed angiogenic markers VEGF and placental growth factor, leading

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June 26, 2025 No Comments

Targeting cancer stem cells and signaling pathways by phytochemicals: Novel approach for breast cancer therapy

This review article explores the potential of phytochemicals in targeting breast cancer stem cells (BCSCs) and associated signaling pathways. It discusses various plant-derived compounds, such as curcumin, genistein, resveratrol, and sulforaphane, highlighting their mechanisms in inhibiting BCSC proliferation, inducing apoptosis, and modulating key pathways like Wnt/β-catenin, Notch, Hedgehog, and PI3K/Akt/mTOR.

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June 26, 2025 No Comments

Novel Repositioning Therapy for Drug-Resistant Glioblastoma: In Vivo Validation Study of Clindamycin Treatment Targeting the mTOR Pathway and Combination Therapy with Temozolomide

This 2022 study evaluates the repurposing of clindamycin (CLD), a macrolide antibiotic, as a novel therapeutic agent for drug-resistant glioblastoma (GBM). CLD was shown to inhibit tumor cell growth by targeting the mTORC1 signaling pathway, reducing phosphorylation of downstream targets p70S6K and S6. Importantly, CLD also suppressed MGMT expression, a

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June 26, 2025 No Comments

Calcium oxalate crystals trigger epithelial-mesenchymal transition and carcinogenic features in renal cells: a crossroad between kidney stone disease and renal cancer

This 2022 study explored the effects of calcium oxalate monohydrate (COM) crystals on non-cancerous renal cells. COM exposure induced epithelial-mesenchymal transition (EMT), characterized by morphological changes to a spindle shape, decreased epithelial markers (E-cadherin, ZO-1), and increased mesenchymal markers (fibronectin, vimentin). Additionally, COM downregulated tumor suppressor genes (ARID1A, PTEN, VHL)

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June 26, 2025 No Comments

Combination Therapy with Vitamin C Could Eradicate Cancer Stem Cells

This review evaluates the role of high-dose vitamin C (ascorbic acid) as a complementary treatment in targeting cancer stem cells (CSCs), which are key drivers of tumor initiation, resistance, and relapse. The authors describe mechanisms by which vitamin C exerts selective cytotoxic effects on CSCs, including induction of oxidative stress

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June 26, 2025 No Comments

Glutathione Peroxidase GPX1 and Its Dichotomous Roles in Cancer

This 2022 review examines the complex and context-dependent roles of Glutathione Peroxidase 1 (GPX1), a selenium-dependent antioxidant enzyme, in cancer. GPX1 reduces hydrogen peroxide and lipid peroxides, thereby mitigating oxidative stress, which can influence both tumor suppression and progression. The review highlights the impact of the Pro198Leu (rs1050450 C>T) polymorphism,

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June 26, 2025 No Comments

Role of glutathione in cancer progression and chemoresistance

This review examines the dual role of glutathione (GSH) in cancer biology, emphasizing its involvement in both cancer progression and chemoresistance. While GSH deficiency increases oxidative stress and may promote carcinogenesis, elevated GSH levels provide antioxidant protection to tumor cells, helping them resist chemotherapy-induced damage. The review highlights the complex

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June 26, 2025 No Comments