This 2020 review explores the complex role of glutathione (GSH) in cancer, emphasizing its dual nature as both a protector against oxidative stress and a contributor to tumor progression and drug resistance. Elevated GSH levels in cancer cells enhance survival, proliferation, and resistance to chemotherapy by detoxifying reactive oxygen species
This 2020 review article explores the multifaceted role of iron in cancer biology. It discusses how dysregulated iron metabolism contributes to tumor initiation, growth, and metastasis. Excess iron can promote oxidative DNA damage and genomic instability, facilitating oncogenesis. The article also examines therapeutic strategies targeting iron metabolism, such as iron
This 2021 systematic review evaluates the effects of naltrexone (NTX), including low-dose naltrexone (LDN), on cancer progression and mortality across human, animal, and cell culture studies. Findings indicate that LDN (3–5 mg/day) may inhibit tumor growth and metastasis, potentially by modulating opioid receptors and immune responses. Conversely, high-dose or continuous
This 2022 review examines the complex and context-dependent roles of Glutathione Peroxidase 1 (GPX1), a selenium-dependent antioxidant enzyme, in cancer. GPX1 reduces hydrogen peroxide and lipid peroxides, thereby mitigating oxidative stress, which can influence both tumor suppression and progression. The review highlights the impact of the Pro198Leu (rs1050450 C>T) polymorphism,
This commentary discusses the use of PSA (prostate-specific antigen) velocity and doubling time as critical factors in making clinical decisions for prostate cancer management. The article examines how changes in PSA levels over time can indicate tumor progression and help guide treatment decisions. It emphasizes the importance of incorporating PSA
This article reviews the potential of commonly used drugs, including antidiabetics, anthelmintics, statins, and beta-blockers, as co-adjuvant therapies in cancer treatment. The study discusses how these drugs, originally used for other medical conditions, may improve cancer outcomes by modulating tumor progression, enhancing immune response, or reducing inflammation. The review highlights
This article explores the potential of betulinic acid as both a cancer treatment and preventive agent. The study highlights betulinic acid’s ability to induce apoptosis in various cancer cell types through the activation of mitochondrial pathways. Additionally, it addresses its anti-inflammatory and anti-angiogenic properties, which may contribute to its effectiveness
This Phase I clinical trial (NCT03051477) evaluates the safety, toxicity, and maximum tolerated dose (MTD) of Helixor® M (mistletoe extract) in 21 patients with advanced solid tumors who have not responded well to first-line therapies. The study consists of a dose escalation phase to assess safety and an expansion phase
This study explored the effects of Hyperbaric Oxygen Therapy (HBOT) on lung cancer progression in a murine xenograft model using A549 human lung carcinoma cells. The results showed that HBOT improved tumor hypoxia, suppressed tumor growth, and induced apoptosis in cancer cells. Additionally, HBOT increased the expression of Platelet Endothelial
