This 2009 randomized, double-blind, placebo-controlled trial assessed the efficacy of magnesium orotate as an adjunct therapy in 79 patients with severe congestive heart failure (NYHA Class IV) already receiving optimal medical treatment. Participants were randomized to receive either magnesium orotate (6,000 mg/day for 1 month, then 3,000 mg/day for 11
This in vitro study evaluated the molecular effects of metformin on prostate cancer cells, specifically the PC-3 cell line. Exposure to 5 mM metformin for 24 to 72 hours resulted in significant changes in the expression of 22 microRNAs (miRNAs), with 10 upregulated and 12 downregulated. Key altered miRNAs included
This 2020 study investigates the anti-metastatic effects of pharmacological ascorbate (P-AscH⁻) in pancreatic ductal adenocarcinoma (PDAC), demonstrating its action via hydrogen peroxide (H₂O₂) generation. In vitro experiments revealed that P-AscH⁻ impairs PDAC cell invasion and matrix degradation, effects reversed by catalase, confirming the role of H₂O₂. In vivo, P-AscH⁻ treatment
This 2017 erratum pertains to a correction of the original 2016 publication that investigated the ototoxic potential of artesunate when administered as an add-on therapy in patients with metastatic or locally advanced breast cancer. The original study, a phase I trial, was prospective, open-label, and single-center in design, aiming to
This 2018 review examines several adjunct therapies for pancreatic cancer that have shown promise in preclinical models and retrospective studies. Paricalcitol, a vitamin D analog, disrupts the tumor stroma, enhancing drug delivery. Hydroxychloroquine inhibits autophagy, a survival mechanism in cancer cells. Intravenous vitamin C induces cytotoxic hydrogen peroxide accumulation in
This addendum investigates the role of melatonin in enhancing overall survival in prostate cancer patients with poor prognosis following combined hormone and radiation therapy. The study shows that melatonin improves patient outcomes by reducing side effects and enhancing the effectiveness of the treatments. It emphasizes melatonin’s potential as an adjunct
This article reviews the antioxidant effects of ascorbic acid (vitamin C) and alpha lipoic acid, particularly in their liposomal forms, as adjuncts in cancer treatment. The study explores how these compounds, through their antioxidant properties, may reduce oxidative stress, enhance chemotherapy efficacy, and protect normal tissues from damage. The review
This review article highlights the use of Viscum album (mistletoe) extracts in oncology, showing evidence that these extracts can improve health-related quality of life (HRQL) and potentially prolong survival in cancer patients. It emphasizes the anti-tumor, immunomodulatory, and pro-apoptotic effects of VA extracts, which are commonly used as adjunct therapies
This 2022 review article published in the International Journal of Molecular Sciences evaluates the role of oxygen-ozone (O₂O₃) therapy in modulating pro-inflammatory cytokines, particularly interleukin-6 (IL-6), in conditions such as temporomandibular disorders (TMD), low back pain, knee osteoarthritis, and rheumatic diseases. The authors highlight that O₂O₃ therapy exerts its effects
This randomized controlled trial examined the effects of magnesium chloride (MgCl₂) supplementation on blood pressure and lipid profiles in 82 diabetic hypertensive adults with low serum magnesium levels. Participants received either 2.5 g of MgCl₂ solution daily (providing 450 mg of elemental magnesium) or a placebo for four months while
