Well Referenced

Tag: neuronal apoptosis

α-lipoic acid exerts neuroprotective effects on neuronal cells by upregulating the expression of PCNA via the P53 pathway in neurodegenerative condition

This 2016 in vitro study investigated the neuroprotective effects of α-lipoic acid (ALA) on dopaminergic neurons exposed to MPP+, a neurotoxin used to model Parkinson’s disease. The researchers found that ALA treatment significantly reduced neuronal apoptosis and increased the expression of proliferating cell nuclear antigen (PCNA), a key protein involved

Read More »
June 26, 2025 No Comments

Discovery that a melanocortin regulates sexual functions in male and female humans

This study investigated the use of curcumin-loaded gelatin nanoparticles (Cur@GAR NPs) functionalized with rabies virus glycoprotein (RVG29) to enhance brain-targeted therapy for ischemic stroke. In vitro, these nanoparticles improved curcumin’s solubility, stability, antioxidant, and antimicrobial properties. In vivo studies using a middle cerebral artery occlusion (MCAO) rat model demonstrated that

Read More »
June 26, 2025 No Comments

Hyperbaric Oxygen Therapy Alleviates Memory and Motor Impairments Following Traumatic Brain Injury via the Modulation of Mitochondrial-Dysfunction-Induced Neuronal Apoptosis in Rats

This animal study investigated the neuroprotective effects of hyperbaric oxygen therapy (HBOT) in rats with traumatic brain injury (TBI). The results showed that HBOT significantly improved motor and spatial learning performance, reduced cortical neuronal loss, and decreased the apoptosis marker cleaved-Caspase3. Additionally, HBOT preserved mitochondrial respiration functions and modulated glial

Read More »
June 26, 2025 No Comments

Progesterone receptor replenishment in T47D human breast cancer cells. Roles of protein synthesis and hormone metabolism

This study examines the neuroprotective effects of progesterone following cerebral ischemia and reperfusion injury in rats. The findings show that progesterone administration significantly preserves mitochondrial function and reduces neuronal apoptosis in the brain regions affected by ischemia. These results suggest that progesterone may offer therapeutic benefits for mitigating ischemic brain

Read More »
June 26, 2025 No Comments